The foutain of youth?

Allen Smith allens at yang.earlham.edu
Fri Apr 17 14:23:24 EST 1992


In article <robison1.703374498 at husc10>, robison1 at husc10.harvard.edu (Keith Robis
   on) writes:
>>To preserve the age of a multi-celled organism, the differentiated
>>state (methylation pattern) of the DNA in each cell must be preserved.
>>Thus it would be necessary to generate duplicate copies of each cell's
>>chromosomes (preserving the DNA from a single body part would not work).
>
>
> Fatal flaw:  Most metazoans (multi-cellular animals) do not methylate
> their DNA to a detectable extent.  A particular example is Drosophila,
> which clearly ages.  Methylation in metazoans largely appears to be
> a mammalian anomaly.
>
> People are looking for ageing genes in Drosophila -- there was a blurb
> on it in a recent Science (the one before the format change).
>
>
        Different organisms, however, may certainly have different aging
mechanisms. Senesence in non-mammalian metazoans is not the same as in
mammals, for instance.
        -Allen




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