The foutain of youth?
robison1 at husc10.harvard.edu
Wed Apr 15 16:48:18 EST 1992
french at RUST.ZSO.DEC.COM writes:
>To preserve the age of a multi-celled organism, the differentiated
>state (methylation pattern) of the DNA in each cell must be preserved.
>Thus it would be necessary to generate duplicate copies of each cell's
>chromosomes (preserving the DNA from a single body part would not work).
Fatal flaw: Most metazoans (multi-cellular animals) do not methylate
their DNA to a detectable extent. A particular example is Drosophila,
which clearly ages. Methylation in metazoans largely appears to be
a mammalian anomaly.
People are looking for ageing genes in Drosophila -- there was a blurb
on it in a recent Science (the one before the format change).
Program in Biochemistry, Molecular, Cellular, and Developmental Biology
robison at ribo.harvard.edu
More information about the Ageing