Why does calorie restriction reduce the rate of aging?

Dallman Ross dman at netcom.com
Fri Aug 21 17:54:52 EST 1992

rbradbur at hardy.u.washington.edu (Robert Bradbury) writes:
:                                     When food is scarce, reproduction
: is not a particularly good idea.  Instead an organism would have a
: selective advantage if it could put the resources which would normally
: go into reproduction into preserving the organism until such time as
: times got better and food resources would allow better offspring survival.
So, are you saying that we'll live longer but without any sex drive?
Longer, but less pleasure?

:   2) Protein synthesis is expensive from an energy requirement standpoint.
:      How can an organism get less overall energy and yet increase its
:      protein breakdown and synthesis?  One saves some energy because
:      you do not have the losses associated with building up/breaking
:      down fatty acids.  There also seems to be a less cell replication
:      due to lower growth hormone/T3 levels.  Do these and the slightly
:      lower temperatures provide enough energy savings to be able to
:      increase protein synthesis with 40% less calories or is there
:      something I am missing?
Not sure on that one; but it is clear that less cell replication equates
to less oncogenetic mutation.

Good report.  Thanks.

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