Speculation on error correction [Re: The fountain of youth.]
robison1 at husc10.harvard.edu
Tue May 19 12:11:52 EST 1992
rbradbur at hardy.u.washington.edu (Robert Bradbury) writes:
>In article <1992May14.205658.18282 at sci.ccny.cuny.edu> dac at sci.ccny.cuny.edu
> (David A Cooke) writes:
>> I refuse to believe that the prime cause of aging is DNA damage,
>>no matter how many times you repeat it, Larry. Until I see some actual
>>scientific evidence for that, I think the question of replacing the human
>>genome is moot.
>Ask and you shall receive....
I must confess to being a complete doubter -- until yesterday morning.
I did a MEDLINE search on progeria, a syndrome marked by hyperaccelerated
aging. Much to my surprise, several references had found reduced DNA
repair activity in cells from progeria paper. Not a smoking gun,
but quite suggestive (I didn't save the references -- sorry).
Program in Biochemistry, Molecular, Cellular, and Developmental Biology
robison at ribo.harvard.edu
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