Ageing in C. elegans

Sydney Shall S.Shall at sussex.ac.uk
Mon Dec 20 09:46:30 EST 1993


Vuaghn Gehle has offered a possible explanation for the long-lived C.
elegans mutant that Cynthia Kenyon et al have recently described.  I
wonder if there is supporting data indicating the damaging effects of
oxygen radicals in those cases where SOD or another enzyme is thought
to be defective.  I have in mind increased protein damage and
particularly increased DNA damage.  I wonder how much of an increase
in oxygen radicals cells (or organisms) can meet without displaying
(a) signs of increased damage and (b) lethality.

	Sydney SHALL


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Sydney SHALL,
Laboratory of Cell and Molecular Biology,
Biology Building,
University of Sussex,
Brighton,
East Sussex BN1 9QG,
ENGLAND.

Telephone: +44.273.67.83.03

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