fas gene

Matthew J. Brauer mjbrauer at well.sf.ca.us
Sat Apr 16 02:53:35 EST 1994


VERPHELD at VTVM1.CC.VT.EDU writes:

>Autoimmune prone MRL/lpr mice have been reported to have deffective Fas genes
>which would presumably alter the negative selection process in the thymus.  I
>would like to know if anybody has any thoughtson why this deffective fas gene w
>ould alter T cell development and yet have no effect on other developmental
>processes mediatred through apoptosis.
>************************************************************************
>  Daniela I. Verthelyi
>  Virgina Tech.
>  USA
>  VERPHERLD at VTVM1

Induction of apoptosis probably proceeds through any of several pathways,
of which fas-mediated apoptosis is only one.

Many of the downstream apoptosis genes (e.g. bcl-2, bax, etc.) show
tissue-specific expression. It's conceivable that the signalling pathway
in developing lymphocytes is more finely modulated than in other tissues.

Matthew J. Brauer




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