fas gene

glover martin gwmartin at husc9.harvard.edu
Sat Apr 16 16:21:40 EST 1994


VERPHELD at VTVM1.CC.VT.EDU wrote:
: Autoimmune prone MRL/lpr mice have been reported to have deffective Fas genes
: which would presumably alter the negative selection process in the thymus.  I
: would like to know if anybody has any thoughtson why this deffective fas gene w
: ould alter T cell development and yet have no effect on other developmental
: processes mediatred through apoptosis.
: ************************************************************************
:   Daniela I. Verthelyi
:   Virgina Tech.
:   USA
:   VERPHERLD at VTVM1

Could there be many ways to start the "program" of apoptosis?  If this is 
the case, could fas be T-cell/T-cell precursor specific?

Trei




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