Carnosine and male reproductive tissues

Dr Jim Cummins cummins at POSSUM.MURDOCH.EDU.AU
Mon Dec 12 22:23:46 EST 1994

Some months back there was a a flurry of interest on Carnosine and its
apparent effects on ageing.  In June  RATTAN at wrote:

: Recently, two new discoveries have been published claiming certain
: anti-ageing effects on human cells in culture. This week in the journal
: (of Holliday junction fame) has published senescence-retarding effects
: of a dipeptide beta-alanyl-L-histidine, called carnosine, on human
: fibroblasts. Maintenance of young morphology along with some other
: cellular and biochemcial characterisitcs is the main effect seen. There is
: a slight increase in cell proliferation too. Even senescence characteristics
: can be reversed. Of course, at this stage nothing is known about the
: mode of action of such a dipeptide in bringing about so big changes
: in cellular physiology, ageing and lifespan. 

I've been doing some further reading and certainly carnosine and other
dipeptides have interesting antioxidant, metal chelating and membrane
stabilizing properties.  Can I ask the collective wisdom  if anything is
known about the distribution of carnosine and related peptides in
reproductive tract tissues?  I'm following this focus as ROS-induced lipid
peroxidation is a potent source of sperm dysfunction in infertile men, and
it would be fascinating if carnosine (or lack of) is involved.

Yours, virtually:-

Jim "Spermatology rules o~ o~ o~ o~" Cummins

Associate Professor in Veterinary Anatomy
Murdoch University,
Murdoch Western Australia 6150
Tel +61-9-360 2668
Fax +61-9-310 4144
E mail cummins at

"Ignorance is a renewable resource"  PJ O'Rourke.

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