Anti-ageing news

R. M. C rmc at netcom.com
Fri Jun 24 18:31:48 EST 1994


RATTAN at kemi.aau.dk wrote:
: Here is the news of the second anti-ageing discovery.
: Plant hormone KINETIN delays the onset of many cellular and biochemical
: characteristics associated with cellular ageing of cultured human cells.
: Most importantly, these effects are achieved without interfering with the
: maximum proliferative capacity. No additonal cell divisions are induced.
: This is unlike all other anti-ageing things reported for cell cultures
: for example, FGF, PDGF, ginseng, or the latest I reported last week, 
: carnosine. All those things induce additional cell divisions which can
: be potentially harmful in terms of making cells move on a path to
: immortalization (here meaning cancer.)

I can think of a situation where the cell division rate is high but 
because the gene repair mechanism is also extremely effective as to 
result in less carcinogenesis than a converse situation wherein cellular 
damage and malfunctioning of gene repair causes low cell division rate 
but high carcinogenesis


: Kinetin is N6-furfunyadenine, a modified base that can get incorporated
: in tRNA. It is a synthetic cytokinin. Its nearest natural relative is
: zeatin, but in our experiments Kinetin is the most effective.

: A small free-base, modified a little, having such dramatic effects!!!! 
: Various other modifications do not have similar effects, or may be
: very small effects. Also, it has to be free-base and not the nucleoside
: or neucleotide. Apparantly, in plants it does not matter, but in human 
: cells it can be a difference of life and death.

Not surprisingly, many what would be considered by-products of plant 
metabolism (eg. alkaloids) or waste, turns out to have wonderous 
therapeutic effects in animals such as man.

: Natural sources of kinetin related cytokinins are: very high levels
: in coconut water/milk; all germinating seeds and growing tips etc.

Now, this is interesting.  Germinating seeds and growing tips presumably 
have a high cell division rate, so there must be some other compound(s) 
that promote cellular division and yet works in conjunction with these 
kinetin related cytokinins.  Their high concentration in the germinating 
phase may suggest their protective effect against errors in DNA 
transcription (and/or RNA) during the cell proliferation stage.  Therefore:
(a) Study the effect of kinetin by depletion or enrichment during various 
phases of (1) plant and (2) animal cell growth as well as various phases 
of the entire plant or animal

: Potential usages as nutrional supplement, anti-oxidative compounds, 
: and rejuvenator.

: The paper: Kinetin delays the onset of ageing characteristics in human
: fibroblasts, by SIS Rattan & BFC Clark is in Biochemical Biophysical
: Research Communications, vol 201, pages not sure, 1994.

As far as the financial aspects of this research, let me say that I have 
been interested in aging research since age of about 11.  However, my 
colleagues and I have researched the stock market and are now able to 
forecast prices very accurately.  See if some medical foundations are 
interested in sponsoring your research in return for us providing them 
extremely valuable investment forecasts (whereby 50 -100% annual return 
is quite normal).

: So much for the good week end news.

Certainly very interesting.  Keep up the good work and do post here often.

Sample forecasts follow:
(these were made prior to the opening of the U.S. financial markets on 
the evening of June 23, 1994.  As you can see, we expected the U.S. stock 
market to drop the next day, today, which did happen.)


Subject: Advance Price Forecasts on S&P 100 Stocks (6/23/94).

Summary: Stock Price Forecasting is NOT a Dismal Science

Distribution: world.

***********************************************************
MARKETSCOPE(tm) PRICE FORECASTS ON MAJOR U.S. COMMON STOCKS
***********************************************************
Stock |Company name sorted by |Closing |<%Percent Change>
ticker|its stock ticker symbol|price on|  1-3   2-6   3-9
symbol|in ascending order     |06/23/94|  Wks   Wks   Wks
***********************************************************
AA     Aluminum Co. of America   74.750    -2    -2    -3
AEP    American Electric Power   28.125    -1    -1     1
AGC    American General          28.500     1     6    10
AIG    American Int'l Group      92.500    -2    -2    -2
AIT    Ameritech                 41.125    -2    -3    -5
AMP    AMP Inc.                  67.000     0    -1    -1
AN     Amoco                     59.000    -2    -1    -1
ARC    Atlantic Richfield       101.875    -1    -1    -1
AVP    Avon Products             58.500    -1    -1    -1
AXP    American Express          26.750    -3    -6    -7
BA     Boeing Company            47.875    -2    -3    -3
BAC    BankAmerica Corp.         46.625    -3    -4    -4
BAX    Baxter International Inc. 25.500    -3    -3    -3
BC     Brunswick Corp.           23.625     1     1    -1
BCC    Boise Cascade             23.625    -1    -1    -3
BDK    Black & Decker Corp.      17.750     1     2     3
BEL    Bell Atlantic             55.375     1     1     2
BHI    Baker Hughes              21.625    -2    -3    -5
BMY    Bristol-Myers Squibb      54.750    -1    -2    -2
BNI    Burlington Northern       54.250     0     0     1
BS     Bethlehem Steel           19.375    -5    -5    -6
CCB    Capital Cities/ABC        73.375   -15   -17    -8
CCI    Citicorp                  39.125    -4    -4    -5
CEN    Ceridian Corp.            24.875    -1    -1    -1
CGP    Coastal Corp.             28.000    -1     1     1
CHA    Champion International    33.000    -1    -2    -3
CI     CIGNA Corp.               71.000    -1    -2    -4
CL     Colgate-Palmolive         53.000     6    -4    -5
CSC    Computer Sciences Corp.   42.250     0     0     1
CWE    Commonwealth Edison       23.250     1     4     4
DAL    Delta Air Lines           45.875    -1    -1    -1
DD     Du Pont (E.I.)            59.750     0    -1    -1
DEC    Digital Equipment         20.375     2     2     2
DIS    Walt Disney Co.           42.625    -3    -3    -4
DOW    Dow Chemical              67.000    -2    -3    -3
EK     Eastman Kodak             47.500     1     0    -1
ETR    Entergy Corp.             24.875    -1     0     4
F      Ford Motor                57.375    -4    -5    -5
FDX    Federal Express           76.000    -1    -1    -1
FLR    Fluor Corp.               51.500    -3    -4    -5
FNB    First Chicago Corp.       48.375    -3    -3    -5
GD     General Dynamics          42.125    -3    -3    -3
GE     General Electric          46.250    -1    -1     7
GM     General Motors            50.750    -5    -7    -9
GWF    Great Western Financial   18.875     4    11    12
HAL    Halliburton Co.           34.750    -2    -1     1
HM     Homestake Mining          19.750    -2    -5    -4
HNZ    Heinz (H.J.)              33.250     0     0     1
HON    Honeywell                 31.375    -1     0     1
HRS    Harris Corp.              45.750    -5    -5    -5
HWP    Hewlett-Packard           76.375    -3    -5    -5
I      First Interstate Bancorp  75.500     1    -1    -2
IBM    International Bus. Machin 60.875    -3    -3    -3
IFF    International Flav/Flag   40.000    -1    -1    -2
IMA    IMCERA Group Inc.          8.625    -1    -1    -3
INTC   Intel Corp.               58.375     0     0     1
IP     International Paper       69.000    -2    -2    -2
ITT    ITT Corp.                 82.500    -2    -3    -3
JNJ    Johnson & Johnson         43.250     1     0     0
KM     K Mart                    15.875    -2     0     0
KO     Coca Cola Co.             40.500    -1    -2    -2
LIT    Litton Inds.              33.875     3     6     7
LTD    Limited, The              17.500    -5    -6    -9
MCD    McDonald's Corp.          59.375     1     1     1
MCIC   MCI Communications        23.063    -3    -2    -1
MER    Merrill Lynch             36.500    -1    -3    -3
MMM    Minn. Mining & Mfg.       50.875     1     1     1
MOB    Mobil Corp.               83.875    -1    -1    -1
MRK    Merck & Co.               30.500     1     1     0
MTC    Monsanto Company          77.500     0    -1    -1
NSC    Norfolk Southern Corp.    63.500    -3    -3    -3
NSM    National Semiconductor    17.500   -10   -11   -11
NT     Northern Telecom          28.750    -8    -9   -11
OXY    Occidental Petroleum      19.750    -6     0    -1
PCI    Paramount Comm. Inc.      48.000     2     2     2
PEP    PepsiCo Inc.              31.125    -7   -12   -13
PRD    Polaroid Corp.            32.625    -2    -3    -3
PRI    Promus Inc.               29.500    -2    -1    -7
RAL    Ralston-Ralston Purina Gp 35.875     0     0     1
ROK    Rockwell International    38.000    -1    -1    -1
RTN    Raytheon Co.              64.875     1     1     2
S      Sears, Roebuck & Co.      46.125    -5    -7    -7
SKY    Skyline Corp.             19.375     0     0    -1
SLB    Schlumberger Ltd.         60.125    -3    -1     0
SO     Southern Co.              19.000    -2    -3    -3
T      American Tel. & Tel.      55.250    -2    -3    -3
TAN    Tandy Corp.               35.875    -1    -2    -3
TDY    Teledyne Inc.             17.125    -1    -1    -1
TEK    Tektronix Inc.            30.000     4     4     5
TOY    Toy R Us                  34.125    -1    -1     1
TXN    Texas Instruments         74.125    -5    -6    -6
UAL    UAL Corp.                125.125     0     3     4
UIS    Unisys Corp.               8.875   -23   -34   -31
UPJ    Upjohn Co.                30.875    -1     3     4
UTX    United Technologies       65.125    -2    -2    -2
WMB    Williams Cos.             28.375    -3    -4    -5
WMT    Wal-Mart Stores           24.250    -2    -2    -1
WY     Weyerhaeuser Corp.        40.125    -1     0     1
XON    Exxon Corp.               58.125    -3    -3    -4
XRX    Xerox Corp.               98.125    -3    -3    -3
***********************************************************
Above forecasts are dated and perishable analyses derived
from data and sources presumed to be reliable overall but
we can guarantee neither accuracy nor profitability. 

Please note that dramatic or unusual market developments  
may intensify, diminish or even reverse the earlier fore-
casts. Daily computer analysis will yield the best results. 

Please disregard the forecasts on any stock that has had a
stock split within the last three months as the forecasts 
will not be meaningful.  Wait for three months to elapse.

Above forecasts are neither "advice" nor "recommendations".
The forecasts are provided "as is", courtesy of R.M.C., the
leader in price forecasting systems, software and research.
R.M.C. publishes MarketMaster(tm), the world's FIRST and  
ONLY price forecasting software that generates LEADING 
INDICATORS to forecast the DIRECTION, MAGNITUDE, and TARGET
of future price movement of any stock, index or future.

Call (408)-RED-HOT-STOCKS (voice) OR (408)-733-4687 for a
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The forecasts herein MAY BE FREELY DISTRIBUTED WORLDWIDE
in their original, intact form.  Editors and publishers
MAY FREELY USE OR QUOTE the forecasts provided that they
attribute the source fully (i.e. show address and phone.)

R.M.C., P.O. Box 60842, Sunnyvale, CA 94088-0842, U.S.A. 
R.M.C.'s Internet E-MAIL Address is: rmc at netcom.com 
Copyright(C) 1994 BY R.M.C. Phone:(408) 773-8715 (voice).
***********************************************************

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We plan to eventually cover ALL major stocks exchanges in
the world, perhaps as soon as December, 199[ ] (your guess).

Best wishes to your continued success in advancing the knowledge of human 
aging process.






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