Melatonin-dose for anti-aging

Jo Robinson jor at teleport.com
Fri Dec 1 17:57:20 EST 1995


Kevin Goldstein (keving at primenet.com) wrote:
: In article <49gh7j$i48 at maureen.teleport.com> jor at teleport.com (Jo Robinson) writes:

: * snip *

: >        If you want to continue to experiment with melatonin, I suggest
: >that you switch brands (in case the #2 explanation applies) and take
: >a much smaller dose, perhaps 500 micrograms --- 0.5 milligrams.  I have
: >a good friend who took a 3 mg. dose of KAL brand melatonin and was
: >awake all night long.  A very bizarre experience.  She switched to
: >another brand (Life Extension) and dropped the dose down to 1 mg.
: >She slept like a log and has had no trouble ever since.
: *snip*
: >|       Jo Robinson                 |            jor at teleport.com             

: A question on dosages, Jo. How much are you feeding your rats (mice?) in your 
: experiement?

	** Mice.  They get 1 mg of melatonin per liter of water.  I take
the melatonin water away in the daytime so they only have the hormone at
night.
/l.  
	 And do you know what that amounts to in mg/kg?

	The melatonin-treated mice weigh, on average, 37 grams when
last weighed.  The control mice -- 33.3 grams.  If you've visited my
home page recently, you can see the difference in size at a gland.
	 Also, do you know 
: what the doses were in some of the published studies that showed life 
: extension properties for mice? (Again in mg/kg, since I don't know how much 
: those critters drink in a day.)
	I surely do.  In the Maestroni/ Pierpaoli experiments, the mice
were given 10 micrograms per ml.  In the Oaknin-Bendahan study, the rats
were given 4 mg/liter.   

: Well, OK, that was three questions.
	That's all?

	Jo

To see the mice, go to http://www.teleport.com/~jor

--
+-----------------------------------+-----------------------------------------+
|       Jo Robinson		    |            jor at teleport.com             |
|      (503)284-4676                |     2826 NE 18th Portland, OR 97212     | 
+-----------------------------------+------------------------------------y-----+




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