Fusions of Aging Cells

Sean Stevens stevens at rockvax.rockefeller.edu
Wed Dec 27 13:12:55 EST 1995

To those interested,

	I have not been able to keep up with the primary literature involved, 
but I recall a few years back a number of articles discussing the 
results of fusing 'aging' cells, such as WI38 fibroblasts and 
immortalized cell lines such as HeLa. There appeared, at least in some 
cases, to be a dominant 'factor' coming from the aging cells. 
Additionally, there were papers suggesting that aging WI38 fibroblasts 
could condition media such that its transferrence to naieve plates of 
cells caused the hallmarks of the more aged cells. Is research of this 
nature coninuing? Has anyone narrowed down what factor(s) may be 
involved (ie transfected cDNAs derived from aging cells, etc.?)

	Just curious in stimulating discussion.

Sean Stevens  
stevens at rockvax.rockefeller.edu

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