To Asian/Oceanian Colleagues

Leonid Gavrilov gavrilov at ilr.rc.ac.ru
Thu Feb 9 04:58:26 EST 1995



Dear Asian/Oceanian Colleagues,

   Recently our gerontological research group in Russia have made 
some scientific discoveries which we are going to present at 
5th Asia/Oceania Regional Congress of Gerontology (19-23 November, 
1995, Hong Kong). 

   We have submitted our results to the Gerontological Congress 
in the form of two abstracts printed below: 

    1. HUMAN LONGEVITY GENES ARE LOCATED IN  X-CHROMOSOME

    2. BIOMEDICAL BASIS OF SEX DIFFERENTIAL IN HUMAN LIFE SPAN.

   Your comments on these abstracts would be greatly appreciated. 

   Unfortunately we did not get fax connection so far to the Scientific 
Secretariat of the Congress (fax: (852) 519-8072) from Moscow. 

   Would it be possible to pass our abstracts to the Organizing 
Committee of the Congress and to ask them for their E-mail address 
in view of communication problems by fax and regular mail ? 

   Thank you in advance for your kindness.
 
   Sincerely yours,

   Dr.Leonid A.Gavrilov, Ph.D.

**************************************************************************
TO: 

Scientific Secretariat of the 
5TH ASIA/OCEANIA REGIONAL               
CONGRESS OF GERONTOLOGY              
c/o Gardiner-Caldwell Communications Ltd.
2403 Tung Wai Commercial Building 
109-111 Gloucester Road, Wanchai 
Hong Kong 
Fax:  (852) 519-8072 

FROM: 

Dr. Leonid A.Gavrilov,Ph.D. <aeiveos at glas.apc.org>
A.N.Belozersky Institute
Moscow State University
Moscow 119899, Russia
Fax: 7 (095) 939-0338 or 7 (095) 939-3181 	

February 8, 1995

Dear Colleagues, 

      Please find printed below two abstracts submitted to the Congress of 
Gerontology: 

    1. HUMAN LONGEVITY GENES ARE LOCATED IN  X-CHROMOSOME

    2. BIOMEDICAL BASIS OF SEX DIFFERENTIAL IN HUMAN LIFE SPAN.

      Copies of these abstracts were also sent by regular mail. 

      Would it be possible to acknowledge the receipt of this message to
my fax numbers in Moscow:

          7 (095) 939-3181  and  7 (095) 939-0338

and to my E-mail addresses: 

                     aeiveos at glas.apc.org
                     gavrilov at ilr.rc.ac.ru

   I would also greatly appreciate your electronic mail addresses for
rapid and reliable communication since it is very difficult to get fax
connection from Russia to Hong Kong.

   Thank you in advance for your kindness.
 
   Sincerely yours,
   Dr.Leonid A.Gavrilov
______________________________________________________________________
                           *Subject/field of interest code :   2 | 0 


HUMAN LONGEVITY GENES ARE LOCATED IN X-CHROMOSOME. 
 L.A. Gavrilov,  N.S. Gavrilova,  V.G. Semyonova,  A.L. Gavrilova, N.N.
Evdokushkina, N.P.  Snarskaya,  A.N.Belozersky Institute, Moscow State
University, Moscow 119899, Russia and  R.J.Bradbury, Aeiveos Corporation,
Seattle, USA.
  The purpose of the study is to locate the longevity genes
in human genome. If these genes are located in X-chromosome, then
age-related accumulation of mutational load in paternal germ cells should
result in decrease of longevity among daughters only (since paternal X-
chromosome is inherited by daughters only). Thus, the purpose of the study
was to check the prediction of the above mentioned hypothesis that
paternal age at reproduction should be associated with specific decrease
of daughter's longevity.  Information on longevity of sons and daughters
combined with information on paternal age at reproduction was extracted
from genealogical publications and biographic dictionaries. The data (for
more than 3,000 sons and 2,000 daughters) were computerized and sorted by
paternal age at reproduction. Then the mean life span for sons and
daughters was calculated for different paternal ages and the statistical
analysis was made by standard methods (Student test).  It was found that
longevity of the sons is the same for different paternal age subgroups.
Quite different result is observed for daughters: mean life span of the
daughters born by old fathers (50-59 years) was significantly lower than
for daughters born by young fathers (20- 29 years). The difference in mean
life span between these two groups is more than 6 years and this
difference is statistically highly significant (p<0.01).  The obtained
results support the prediction of the hypothesis that human longevity
genes are located in X-chromosome. That is why the accumulation of
mutational load in germ cells of old fathers is detrimental for longevity
of daughters only.



_______________________________________________________________________

                          *Subject/field of interest code :   1 | 9


BIOMEDICAL BASIS OF SEX DIFFERENTIAL IN HUMAN LIFE SPAN N.S.Gavrilova,
V.G.Semyonova, L.A.Gavrilov, A.L.Gavrilova, E.V.Lapshin, N.P.Snarskaya,
G.N.Evdokushkina,   Institute for System Analysis, Russian Academy of
Sciences, pr.60 Let Oktyabrya, 9, Moscow, 117312, Russia
    The purpose of the study is to understand why women live longer than
men. If gender gap is caused by higher genetic redundancy of women's genome
(two X-chromosomes) then accumulation of mutational load in one of the female
X-chromosomes should result in decrease of sex differential in human
lifespan. Thus, the purpose of the study was to check the prediction of
the above mentioned hypothesis that paternal age at reproduction should be
associated with decrease of the gender gap in human longevity (through
introduction of genetic load into female X-chromosome).  Data on longevity
of men and women combined with data on paternal age at their birth were
extracted from genealogical publications and biographic dictionaries. The
data (for more than 3,000 males and 2,000 females) were computerized and
sorted by paternal age at their birth. Then the mean gender gap in
longevity was calculated for different paternal ages and the statistical
analysis was made by standard methods (Student test).  It was found that
gender gap in longevity is a function of paternal age: the highest gender
gap is observed  for the offspring of young fathers (20-29 years), while
for the offspring of old fathers (50-59 years) women DO NOT live longer
than men.  The obtained results support the prediction of the hypothesis
that gender gap in human longevity is caused by higher genetic redundancy
of women's genome (two X-chromosomes).  The research described in this
abstract was made possible in part by Grants N7X000, M7E000 and SBI000
from the International Science Foundation and by INTAS Grant 93- 1617.

__________________________________________________________________________





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