Info needed on G3PD

Patrick O'Neil patrick at corona
Fri Feb 10 01:12:39 EST 1995



On 28 Jan 1995, Barani wrote:

>  I am looking forward to any information towards structural aspects
>  or biochemical activity changes of Glyceraldehyde-3(?)-phosphate-
>  dehydrogenase or its derivative enzymes that are involved in muscular 
>  activities in the heart.  Has there been any work on any conformational 
>  changes or loss of activity of this enzyme in heart-patients? I 
>  strongly presume that there is. 

I am just curious as to why you strongly presume GAPDH loss of 
function/reduced function for this glycolysis enzyme?  Loss of function 
of this enzyme would effectively stop glycolysis and both the aerobic and 
anaerobic metabolism...they wouldn't just have a heart problem, they 
would be dead.




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