Alzheimer's Disease: A Treatment Strategy

jarice at delphi.com jarice at delphi.com
Fri Jan 13 03:04:32 EST 1995


Oral Tolerance

"Oral tolerance is a long recognized method to induce peripheral 
immune tolerance. The primary mechanisms by which orally 
administered antigen induces tolerance are via the generation of 
active suppression or clonal anergy. Low doses of orally 
administered antigen favor active suppression whereas higher 
doses favor clonal anergy. The regulatory cells that mediate active 
suppression act via the secretion of suppressive cytokines such as 
TGF beta and IL-4 after being triggered by the oral tolerogen. 
Furthermore, antigen that stimulates the gut-associated lymphoid 
tissue preferentially generates a Th2 type response. Because the 
regulatory cells generated following oral tolerization are 
triggered in an antigen-specific fashion but suppress in an antigen 
nonspecific fashion, they mediate bystander suppression when 
they encounter the fed autoantigen at the target organ. Thus it may 
not be necessary to identify the target autoantigen to suppress an 
organ-specific autoimmune disease via oral tolerance; it is 
necessary only to administer orally a protein capable of inducing 
regulatory cells that secrete suppressive cytokines. Orally 
administered autoantigens suppress several experimental 
autoimmune models in a disease- and antigen-specific fashion; the 
diseases include experimental autoimmune encephalomyelitis 
(EAE), uveitis, and myasthenia, collagen- and adjuvant-induced 
arthritis, and diabetes in the NOD mouse. In addition, orally 
administered alloantigen suppresses alloreactivity and prolongs 
graft survival. Initial clinical trials of oral tolerance in multiple 
sclerosis, rheumatoid arthritis, and uveitis have demonstrated 
positive clinical effects with no apparent toxicity and decreases in 
T cell autoreactivity." (55)

There is strong evidence that inflammatory processes are involved 
with AD, via an autoimmune response. This is also the case in 
rheumatoid arthritis. Antiinflammatory drugs which are used in 
arthritis also may have efficacy in AD (51-53), indicating a 
common cause or disease process. Oral tolerization has beneficial 
effects on arthritis. Therefore, it seems logical to assume that it 
might be effective against AD. There is evidence that brain tissue 
of non-human origin is similar enough to human tissue to induce 
AD patient antibody recognition: "Serum from AD patients 
contained antibodies that recognized cholinergic neuronal elements 
in the adult rat brain, namely the medial septum, hippocampus, 
and cortex. Another group of investigators showed that AD serum 
contained antibodies directed against the purely cholinergic 
Torpedo electromotor neurons." (50) Consumption of healthy 
animal brain tissue is not known to have adverse side effects . Oral 
consumption of myelin has succeeded in reducing the frequency of 
Multiple Sclerosis attacks. (56)

I therefore recommend daily or weekly consumption of small 
amounts of healthy animal brain tissue by Alzheimer's patients. 
Preparation should be directed toward leaving the tissue as intact 
as possible.


Alzheimer's Disease Therapy 
Recommendations- A Summary

I suggest 10 mg of deprenyl be taken daily (5 mg with breakfast, 
5 mg with lunch) for any Alzheimer's patient.

I suggest the consumption of 2 grams of Acetyl-L-Carnitine daily 
in divided doses with meals by AD patients.

I recommend the AD patient take three times daily with meals at 
least 400 i.u. of vitamin E, one half gram of vitamin C, 25,000 
i.u. of beta carotene (or, even better, consumption of a high dose 
multivitamin) , and  200 mcg of selenium. Also take 120 mg 
Coenzyme Q10, and 120 mg B-6 in three divided doses. 
Additionally, the patient should try to maximize his/her 
consumption of fruits and green vegetables, striving for five to six 
servings a day.

I suggest consumption of a magnesium supplement sufficient to 
provide 400-800 mg of elemental magnesium per day. Example: 2 
tablets of magnesium chloride (OTC: Slo-Mag) three times a day 
(6 total/day) with meals. This will provide about 400 mg  of 
elemental magnesium per day.

I suggest nightly consumption of 6 to 10 mg melatonin just before 
going to sleep, and  consumption of an additional 3 mg if the patient 
wakes up in the night with at least 4 hours of sleep to go. When 
timed-release melatonin becomes available, I suggest using that. 

I suggest daily hormone replacement therapy with DHEA (one 
capsule in the morning) to achieve youthful DHEA levels for 
Alzheimer's patients. 

I suggest pregnenolone supplementation of 30mg/day initially for 
Alzheimer's patients. Typical dosages vary from 10-100mg/day.

I recommend daily or weekly consumption of small amounts of 
healthy animal brain tissue by Alzheimer's patients. Preparation 
should be directed toward leaving the tissue as intact as possible.

If no antiinflammatory drugs are currently being taken by the 
Alzheimer's patient, I recommend one enteric-coated 325-mg 
aspirin be taken with breakfast, and one ibuprofen tablet be taken 
with dinner.

If the disease continues to progress with all of the above therapy 
modalities, including aspirin and ibuprofen therapy, I recommend 
initial therapy with indomethacin (100-150 mg/day). Due to 
possible exacerbation of gastric problems, discontinue aspirin and 
ibuprofen therapy during indomethacin use. If indomethacin 
cannot be tolerated, then re-initiate aspirin and ibuprofin 
therapy, and try chronic administration of prednisone at low doses 
(10 mg/day or less). Commence a search for a nonsteroidal 
antiinflammatory drug which can be tolerated.
References (Starred references [*] are included in 
this package)

1* Development of pharmacological treatments for Alzheimer-
type dementia. (1994) J. Royal Soc. Med. 87:Supp. 23
2*. "Possible New Test Found for Alzheimer's Disease", Science: 
Vol 266, 11 Nov 1994, pp. 973
3*. "A Potential Noninvasive Neurobiological Test for Alzheimer's 
Disease", Science: Vol 266, 11 Nov 1994, pp. 1051-1053
4. Alternatives in the treatment of memory loss in patients with 
Alzheimer's Disease, Clin Pharm 1991 Jun;10(6):447-56
5. Deprenyl-medication: a strategy to modulate the age-related 
decline of the striatal dopaminergic system (1992) J Am Geriatr 
Soc Aug;40(8):839-847
6*. The pharmacological basis of the beneficial effects of deprenyl 
in Parkinson's and Alzheimer's diseases, J Neural Transm 
(1993) [Suppl]40:69-91
7. Clinical issues of cognitive enhancers in Alzheimer disease 
(1991) Alzheimer Dis Assoc Disord 5 Suppl 1:S25-31
8*. The Pharmacological Profile of Deprenyl and its Relevance for 
Humans: A Personal View (1992) Pharmacology & Toxicology 
70:317-321
9*. Physicians Desk Reference (1994) Eldepryl 2309-2311
10*. Long-term efficacy and safety of deprenyl (selegiline) in 
advanced Parkinson's disease (1989) Neurology 39:1109-1111
11*. Combination of tacrine and selegiline in Alzheimer's disease: 
An open pilot study. 4th Int'l Conference on Alzheimers, S136
12*. Rationale for the use of selegiline in the treatment of 
Alzheimer's Disease. 4th Int'l Conference on Alzheimers, S66
13*. Acetyl-L-Carnitine: A Drug Able to Slow the Progress of 
Alzheimer's Disease? (1993) Ann NY Acad Sci, Vol. 640:228-
232
14*. Acetyl-Carnitine and Alzheimer's Disease (1992) Nutrition 
reviews, 50:5; 142-143.
15*. The role of oxidative abnormalities in the pathophysiology of 
Alzheimer's disease (1991) Rev Neurol 147(6-7):513-25 
[Abstract only included]
16*. Free radicals in brain metabolism and pathology (1993) 
British Medical Bulletin 49:3;577-587
17*. Involvement of Free Oxygen Radicals in B-Amyloidosis: An 
Hypothesis (1994) Neurobiology of Aging 15:4; 443-455
18*. Effects of dopaminergic drugs on superoxide dismutase: 
implications for senescence (1993) J Neural Transm 
[Suppl]40:37-45
19. Neurology (Febuary, 1994) Author: Dr. John Breitner, Duke 
University
20* Discussion on tacrine (1994) Alzheimer Disease and 
Associated Disorders Vol 8, Suppl 2, pp. S58
21*. Coenzyme Q10, iron, and vitamin B6 in genetically-
confirmed Alzheimer's Disease (1992) Lancet 340:671-672
22*. Magnesium Supplements (1994) Physicians Desk Reference 
1793-1798
23*. Melatonin, hydroxyl radical-mediated oxidative damage, and 
aging: A hypothesis (1993) J. Pineal Res 14:151-168
24. Melatonin in human cerebrospinal fluid: Its origin and 
variation with age. Life Sci.(1979) 25:929-936
25*. Plasma melatonin rhythm in in normal aging and 
Alzheimer's Disease (1986) J. Neural Transm. Suppl. 21:494
26. Alterations in nocturnal serum melatonin levels in humans 
with growth and aging (1988) J. Clin. Endocrinol. Metab. 
66:648-652
27. Daily variation in the concentration of melatonin and 5-
methoxytryptophol in the human pineal gland: Effect of age and 
Alzheimer's Disease (1990) Brain Res. 628:170-174
28*. The pineal control of aging: The effects of melatonin and 
pineal grafting on the survival of older mice (1991) Ann. N.Y. 
Acad. Sci. 621:291-313
29. Pineal gland and aging (1991) Aging 3:103-116
30. The aging pineal gland and it's physiological consequences 
(1992) Bioessays 14:169-175
31. Concentrations of serotonin and its related substances in the 
cerebrospinal fluid in patients with Alzheimer's type dementia 
(1992) Neurosci. Lett. 141:9-12
32*. Pituitary-adrenocortical and pineal activities in the aged rat 
(1991) Ann. N.Y. Acad. Sci. 621:256-261
33. Antioxidant capacity of melatonin: A novel action not requiring 
a receptor (1993) Neuroendocrinol. Lett. 15:103-116
34*. Melatonin and sleep in humans (1993) J Pineal Res 15:1-
12
35. Barrett-Connor, E., K.T. Shaw, S.S.C. Chen (1986) New 
England J Med 315:1519
36*. Antiglucocorticoid Effects of DHEA-S in Alzheimer's Disease 
(1992) Am J Psychiatry 149:8, 1125-1126
37. Cognitive effects of corticosteroids (1990) Am J Psychiatry 
147:1297-1303
38. DHEA-S serum levels in normal aging and Alzheimer's Disease 
(1991) Age 14:116-118.
39*. Letter, reply to ref. 36, (1992) Am J Psychiatry 149:8, 
1126
40*. DHEA Gets Respect (1994) Harvard Health Letter, July 
1994 1-3
41*. Reduced plasma DHEA concentrations in Alzheimer's Disease 
(1989) Lancet ii:570
42*. DHEA- the mother steroid: Part I. Immunologic Action 
(1994) Annals NY Acad Sci. 719:553-563
43*. Hormonal intervention: "buffer hormones" or "state 
dependency." The role of DHEA, thyroid hormone, estrogen and 
pypophysectomy in aging. Annals NY Acad Sci. 521:260-273
44*. DHEA-S in the Oldest Old, Aged 85 and Older (1994) Ann NY 
Acad Sci 719:543-552
45*. The Endocrinology of Aging: Can we prevent senescence? 
(1994) Extro 1, pp. 101-128
46. Effects of adrenal androgens on the transplantable human 
prostate tumor, Endocrinology 131:2909-2913
47*. Memory-enhancing effects in male mice of pregnenolone and 
steroids metabolically derived from it (1992) Proc Natl Acad Sci 
USA Mar 1;89(5):1567-71
48*. Inflammatory Mechanisms in Alzheimer's Disease (1994) 
Am J Psychiatry 151:8;1105-1113
49*. 45th Forum in Immunology: Immunological factors in 
Alzheimer's Disease: Implications for therapy (1992) Res. 
Immunol. 143:675-683
50*. Cerebrospinal fluid antibodies: an indicator for immune 
responses in Alzheimer's disease (1992) Res Immunol. 
143:663-667
51*. Neuroimmune Mechanisms in Alzheimer disease 
Pathogenesis (1994) Alzheimer Disease and Associated Disorders 
8:3;149-158
52*. New Alzheimer's Therapy Suggested (1993) Science:260;18 
Jun, pp. 1719-1720
53*. Clinical trial of indomethacin in Alzheimer's disease (1993) 
Neurology Aug;43(8):1609-11
54*. Indomethacin and Indocin (1994) Physicians Desk 
Reference, 1472-1473
55*. Oral tolerance: Immunologic mechanisms and treatment of 
animal and human organ-specific autoimmune diseases by oral 
administration of autoantigens (1994) Annu Rev 
Immunol.12:809-37
56*. Double-Blind Pilot Trial of Oral Tolerization with Myelin 
Antigens in Multiple Sclerosis (1993) Science 259:1321-1324


Alzheimer's Disease- Recommended Action Checklist

	Make an appointment with an opthalmologist and have the 
eye test performed.

	If the results are positive, make an appointment with your 
physician. Bring the results of the patients eye test and this 
package Attempt to get his/her cooperation in your program. If 
you have health insurance, try to get a prescription for deprenyl 
and DHEA. See if any other listed compounds could also be obtained 
via prescription so that your health insurance pays for it. Discuss 
the advisability of commencing Indomethacin or other nonsteroidal 
antiinflammatory drug therapy.

	What you can do without your physician:  Everything 
except Indomethacin or other prescription nonsteroidal 
antiinflammatory drug therapy.

	If you are unable to have the eye test done, and don't wish to 
involve a physician, everything recommended here has general 
anti-aging effects, and can be followed by most elderly persons 
who wish to retain their health.

	Either in consultation with your physician, or on your 
own, order the following products, and begin taking at the 
recommended dosages:

1. From Beyond-A-Century:
1-800-777-1324, phone credit card orders accepted.

200.2-  Life extension mix, low niacin. If you can't take fairly 
large tablets, they do have loose powder which can be mixed with 
water.
4 bottles of 315 tablets- $138
8 bottles of 315 tablets- $245

204.0-  Selenium complex.
1 or 2 bottles of 200mcg x 100 tablets- $5 each

Optional but recommended:
003.5- Performance Extra- Arginine/OKG 2:1 mix, 250 gram 
bottle- $28.75 each


2. From Healing Alternatives Foundation:
Use enclosed photocopy of order form. Must mail-order. Credit 
cards or checks accepted.

Coenzyme Q-10 (150)
1 or 2 bottles 30mg x 100 capsules- $19.42 (Calif. residents 
$20.95).

DHEA-100
1 or 2 bottles 250mg x 100 capsules- $62.87 (Calif. residents 
$67.81).

OR:   If you have health insurance and your doctor is willing, get 
your doctor to prescribe DHEA as hormone replacement therapy at 
his recommended dosage and get from your local pharmacy.

OR:   If you would rather use a credit card and place a phone order 
for DHEA, try:


Atlanta Buyer's Club
(404) 874-4845
AIDS Buyer's Club, takes phone credit card orders.

DHEA- 250mg x 100- Approx. $60.


3. From Life Extension Foundation:
1-800-841-5433, phone credit card orders accepted.

Melatonin
1 or 2 bottles 10mg x 60 capsules- $24 each
1 or 2 bottles 3mg x 60 capsules- $8 each

Acetyl-L-Carnitine
2 to 4 bottles 500mg x 100 capsules- $68 each


4. From A. Werner & Co.
PO Box 615
11121 Prague 1
Czech Republic
Mail orders only, use included photocopy of order form. Send 
airmail. Checks or (recommended) money orders accepted. Could 
be up to 45 days for delivery, so order sufficient quantity. Need 2 
capsules per day.

Deprenyl-100x5 mg capsules-$95, 400x5 mg capsules-$360
Plus $7 shipping.

OR:   If you have health insurance and your doctor is willing, get 
your doctor to prescribe Deprenyl/Selegiline/Eldepryl, 10mg per 
day, and get from your local pharmacy.


5. From Lifelink
445 Liery Lane
Arroyo Grande, CA 93420
(805)473-1389

Pregnenolone: 30mg x 50- $33, or 30mg x 150- $90, or 30mg 
x 500- $270, prescription not required.
Plus $4 shipping.


6. From Local Drug Store:
1 bottle enteric-coated aspirin, 325 to 400 mg tablets- Approx. 
$6
1 bottle Ibuprofin- Approx. $6

7. From Local Meat Market
Fresh, healthy animal's brains. Begin consuming a small amount 
daily or weekly.

Note: All of the above compounds should be refrigerated prior to 
use, with the exception of Deprenyl, which should be stored at 
room-temperature.

Alzheimer's Disease- Treatment Resources

	1. Melatonin- Cost/Day: $0.13 to $0.26. Dosage: One to 
three 3 mg capsules or one 10 mg capsule 1/2 hour before sleep, 
plus an. additional 3 mg capsule if you wake up with at least 4 
hours to go. Source: Life Extension Foundation (1-800-841-
5433), Vitamin Research Products, or Beyond-A-Century. 

	2. Life Extension Mix- Cost/Day: $1.09 to $0.88 
(depending on whether 1,4, or 8 bottles of 315 tablets are bought 
at once). Dosage: 3 tablets with each meal (9 per day). Source: 
Beyond-A-Century.

Life Extension Mix (LEF) contains the following components which 
are specifically called for in my Alzheimer's Treatment Strategy:

Numerous generalized antioxidant and immune system boosting 
compounds (vitamins C, E, etc.)
Vitamin B-6:  200 mg
Magnesium (in chloride, aspartate, and succinate forms): 1 gram
Selenium (in sodium selenate and methionine complex): 100 mcg

Contains 50 antioxidant ingredients based on latest scientific and 
medical research. Example: Vitamin E was shown in a very large 
study to be associated with a 37% reduction in risk of coronary 
disease in men and a 41% reduction for women. Formula updated 
regularly. One of the best high doseage multivitamins on the 
market. This formula is not like a typical multivitamin that you 
can get at a drug store, in two important ways: 1. The 
sophistication of the formula, and 2. The total amounts. L.E. Mix 
contains far more of each component than a typical multivitamin. 
Example: to have the anti-arteriosclerotic effect of vitamin E 
mentioned above, you need to take at least 100 i.u. (International 
Units- a measure of bioactivity) of vitamin E per day. A typical 
mulitvitamin has perhaps 37 i.u.  L.E. Mix has 600 i.u. of vitamin 
E.

Current formula of Life Extension Mix- 9 tablets, capsules or 
powder in three divided doses with meals:

Vegetable Complex
Beta-Carotene (ROCHE)- 25,000 i.u.
Xanthophyll complex-   7500 i.u.
Lycopene complex- 10,000 i.u.
Broccoli concentrate- 500 mg
Cabbage concentrate- 500 mg
Vitamin A- 5000 i.u.

B Complex
B1 (Thiamin HCL)- 250 mg
B2 (Riboflavin)- 50 mg
B3 (Niacin 75 mg, Niacinamide 100 mg)- 175 mg
B5 (Calcium pantothenate)- 750 mg
B6 (pyridoxine HCL)- 200 mg
B12 (ion exchange resin)- 100 mcg
PABA- 50 mg
Folate Triglutamate- 800 mcg
Biotin- 200 mcg

Ascorbate Complex
Vitamin C (from Calcium, Magnesium, and niacinamide 
ascorbates)- 2500 mg
Ascorbyl palmitate- 500 mg
Acerola juice powder- 300 mg

Tocopherol Complex
Vitamin E (D, L- alpha tocopherol acetate)- 300 i.u.
Vitamin E (D- alpha tocopherol succinate)- 300 i.u.

Amino Acid Complex
L-taurine- 500 mg
N-acetyl-cysteine- 200 mg
L-glutathione- 15 mg

Mineral Complex
Magnesium chloride- 800 mg
Magnesium aspartate- 100 mg
Magnesium succinate- 100 mg
Potassium aspartate- 50 mg
Potassium chloride- 49 mg
Calcium citrate- 500 mg
Calcium stearate- 250 mg
Vitamin D- 200 i.u.
Selenium (sodium selenate)- 50 mcg
Selenium (seleno-methionine Nutr 21)- 50 mcg
Optizinc (tm)- 20 mg
Zinc succinate- 15 mg
Chromate (tm) (GTF chromium niacin bound)- 50 mcg
Chromium picolinate- 50 mcg

Plus Cholinergic and  Flavinoid Complexes.

I will assume that the patient is taking this formulation in 
recommending doses for the following supplememental compounds.

	3. Enteric Coated Aspirin- Cost/day: pennies. Dosage:  1 
325mg tablet/day with breakfast. Source: Any drugstore. 

Low-dosage aspirin has a dramatic effect on lowering heart 
disease. In a study of 22,071 physicians over a 60 month period, 
those doctors over 50 years of age taking aspirin had a 44% 
reduction in heart attacks. In people with pre-existing heart 
disease, aspirin reduced the risk by 47%. Those people with heart 
disease that took both aspirin and beta carotene had NO heart 
attacks. It also has an effect on cancer apparently by reducing 
"platelet-aggregability", or the tendency of cells to attach to other 
cells. This is how it prevents heart disease (arteriosclerosis), and 
how it also inhibits cancer's "metastasizing", or spreading, 
because the cancer cell which floats free must anchor itself 
somewhere to begin growing again. Aspirin should be used 
cautiously if at all by persons with diabetic retinopathy or poorly 
controlled high blood pressure; i.e., those at risk of bleeding-type 
disorders.

	4. Ibuprofin- Cost/day: pennies. Dosage: 1 tablet/day with 
dinner. Source: drug store.

Ibuprofin is an anti-inflammatory drug. People who use ibuprofin 
chronically (every day) tend to get Alzheimer's Disease at lower 
rates than those who don't.

	5. Deprenyl or Eldepryl- Cost/day: $1.80 to $4.80. 
Dosage: 10 mg/day.  One 5 mg tablet with breakfast, one with 
lunch. Source: local pharmacy with prescription (100 x 5mg-
$220) or, much cheaper, without prescription, A. Werner & Co. 
(100 x 5mg-$95, 400 x 5mg-$360)

	6. DHEA- Cost/day: $0.68 to $2.00. Dosage: 
approximately 100-250 mg/day. Source: Most (not all) local 
compounding pharmacies($2 for a 100 mg capsule), or Lifelink 
(25mg x 180- $40, 195mg x 50- $40, 195mg x 150- $108, 
195mg x 500- $340), or, cheapest, Healing Alternatives 
Foundation (250mg x 100- $67.81) or Atlanta Buyer's Club 
(250mg x 100- approx $60)

	7. Selenium complex- Cost/day: pennies. Dose- Two 
tablets/day. Source: Beyond-A-Century (200mcg x 100- $5)

	8. Acetyl-L-Carnitine- Cost/day: $2.72. Dose- Four 500 
mg capsules/day. Two with breakfast, and one with lunch and 
dinner. Source: Life Extension Foundation.

	9. Pregnenolone- Cost/day: $0.60. Dose- 10 to 100 mg; 
start with 30mg. Source: Lifelink.

	10. Coenzyme Q10- Cost/day: $0.75 to $0.56. Dose- Four 
30 mg capsules/day. Two with breakfast, one with lunch and 
dinner. Source: Beyond-A-Century, or, cheapest, Healing 
Alternatives Foundation.

	11. Magnesium- Cost/day: $0.10 to $1.50. Dose- None, if 
taking Life Extension Mix. Otherwise, two tablets magnesium 
chloride or one tablet magnesium oxide with each meal. Source: 
drugstore.

	12. Vitamin B-6. Cost/day: pennies. Dose- None, if taking 
Life Extension Mix. Otherwise, 250mg/day. Source: Drugstore or 
mail-order vitamin supply.

	13. Nonsteroidal Anti-Inflammatory Drug- Ex.-
Indomethacin. Cost/day: unknown. Dose Depends on compound. For 
Indomethacin, 100-150 mg/day. Source: Local pharmacy, doctor 
prescribed.

	14. Fruits & Vegetables In Your Diet

A large study, published April 14, 1994, tested whether high-
dose beta carotene and/or a small dose of vitamin E taken for five 
years by men who had smoked for at least 30 years would reduce 
lung cancer. It did not. Carcinogenesis may take longer than 5 
years; if so, the vitamin intake was started too late.  Beta carotene 
has been shown in other studies to prevent impairment of the 
immune system by UV light and inhibit mouth and cervical cancer. 
In another study, beta carotene reduced the risk of heart attacks in 
people with preexisting heart disease by 41%. People with heart 
disease that took both aspirin and beta carotene had NO heart 
attacks. 

The evidence supports taking some beta carotene, and Life 
Extension Mix contains this compound. The amounts of vitamin E 
used in the study were not enough to have any effects, based on 
amounts used in previous studies, so the study has no relevance on 
vitamin E's effectiveness or lack thereof. Bottom line, the 
substances in fruits and vegetables which prevent cancer have not 
yet been completely identified. It may also be that diets high in 
fruits & vegetables are also low in fat, which may be a 
contributing factor for cancer reduction. 

Therefore, good judgement dictates that in addition to strategic 
supplements, one should try to eat as many fruits & vegetables as 
possible.

OPTIONAL BUT RECOMMENDED:

	15. Growth Hormone Releaser-Cost/Day: $.48.  
Performance Powder Extra (Arginine/Ornithine alpha-keto 
glutamate (OKG)) 2:1 mix, 300 gram package, cat. no. 003.5, 
$28.75 for 300 grams). Dosage: Men-2 level tablespoons. 
Women-1 level tablespoon. Source: Beyond-A-Century.

As you age, your body's production of growth hormone declines. 
Certain amino-acid formulations can stimulate growth hormone 
release if taken at the proper time and on an empty stomach. The 
idea is to mimic the natural release of growth hormone by a young 
person. GH is normally released in reaction to two events: 
maximum effort exercise (not just jogging, but the 100 yard 
dash, for example), and sleep. Take on an empty stomach just 
before going to bed (stomach acids associated with foods, especially 
sugar, destroy the amino acids). Start with a low dosage and work 
your way up. Benefits for both men and women include more rapid 
healing, a leaner, more muscular body, and significantly increased 
immune response (ability to fight off disease in all it's forms-
from colds to cancer). When taken before sleep, it increases REM 
sleep and may produce a sense of well-being. It should not be taken 
by someone who has existing cancer. Arginine has recently been 
associated with nitric oxide metabolism in the human body. Nitric 
oxide appears to be very important for many basic processes, 
including blood pressure. Arginine lowers blood pressure, 
perhaps because it is a precursor of NO. Arginine is being added to 
some intraveinous solutions given surgery patients after surgery 
in an attempt to speed healing time.


Resources

Beyond-A-Century
PO Box 713
Greenville, ME 04441
1-800-777-1324

Products offered- most. Free catalog.
Life Extension Mix: Bottle of 315 tablets (35 days worth)- 
$30.62 if 8 bottles bought.
Selenium: 100 x 200 mcg selenium complex-$5
Plus $4.50 shipping.


Life Extension Foundation
PO Box 229120
Hollywood, FL 33022-9120
1-800-841-5433

Melatonin: 60 x 3mg: $8, 60 x 10mg: $24
Acetyl-L-Carnitine: 100 x 500mg: $68


Vitamin Research Products
3579 Hwy 50 East
Carson City, NV 89701
(702) 884-1300 & (800) 877-2447  fax-(800) 877-3292

Products offered-most. A research and vitamin formulation sales 
company similar to LEF Outstanding free research 
newsletter/catalog. Appear to be a conscientious company with 
integrity.


Lifelink
445 Liery Lane
Arroyo Grande, CA 93420
(805)473-1389

DHEA-25mg x 180: $40, 195mg x 50: $40, 195mg x 150: 
$108, 195mg x 500: $340, prescription not required.
Pregnenolone: 10mg x 90: $20, 30mg x 50: $33, 30mg x 150: 
$90, 30mg x 500: $270, prescription not required.
Plus $5 shipping.


Atlanta Buyer's Club
(404) 874-4845

DHEA- 250mg x 100: approx $60, phone credit card orders 
taken.


Healing Alternative Foundation
1748 Market Street, Suite 205
San Francisco, CA 94102
(415)626-2316

Free catalog. AIDS buyers club: must join ($1 first time you 
order)
DHEA: 100 x 250mg capsules: $62.87 ($67.81 for Calif. 
residents)
Coenzyme Q-10: 150 x 30mg: $19.42 ($20.95 for Calif. 
residents)
Plus $6 shipping.


A. Werner & Co.
PO Box 615
11121 Prague 1
Czech Republic

Deprenyl-100x5 mg capsules-$95, 400x5 mg capsules-$360
Plus $7 shipping.

Eye Test for Alzheimer's Disease: Procedure 


1) Prepare a dilute solution of tropicamide (0.01%).

2) Have the patient sit in a semidarkened room for 2 or 3 minutes. 
Measure the resting pupil diameter for 1 minute. Record the average 
value on the data sheet. Then administer one drop of the dilute solution 
of tropicamide to one eye. Note the time. Begin timing from this point.

3) Examine the eye for pupil diameter for 30 seconds at the following 
times after drop administration and record the average value of pupil 
diameter on the data sheet.

Times: 2, 8, 15, 22, 29, 41, and 51 min  after drop administration.

4) Perform the calculations indicated on the data sheet to convert raw 
pupil diameter measurements to percentage changes from the baseline, 
or initial measurement.

5) Plot the percentage changes at the measurement times on the 
included graph. Compare the profile with the already plotted profiles of 
Alzheimer's patients and healthy controls. Which profile more closely 
matches the patients profile?

6) If the profile does not indicate Alzheimer's Disease, then consider 
the possibility of non-Alzheimer's dementia, such as Korsakoff's 
syndrome, multi-infarct demetia, and dementia with an extrapyramidal 
syndrome, and get a doctor's advice on diagnosing and treating the 
problem. If the profile more closely matches the AD patient's profile, 
then proceed with the course of treatment indicated herein, in 
consultation with a physician.




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