free radicals do not cause ageing.

Lou Pagnucco lpagnucco at delphi.com
Sun Jan 29 21:13:19 EST 1995


In responding to Dr. Peter Proctor <proctorp at delphi.com>,
Dr Jim Cummins <cummins at POSSUM.MURDOCH.EDU.AU> wrote:
 
>You wrote:
>
>>   Don't confuse the experimental difficulties and the limitations
>>of ( e.g., ) antioxidant supplimentation with evidence against
>>a role for free radiacals in aging.  We may be looking at the wrong
>>thing.  E.g., antioxidants may not work in mitochondrial radical-induced
aging.
>>
>>After over 25 years of research in this area, I still get
>>suprised.  Look at PBN-- It seems to derive its antiaging activity
>>from * production * of a free radical, nitric oxide ( according
>>to Cutlers group at NIH ).
>
>
>Do you have references for this, please?  I agree with your point on the
>paradoxical effects of free radicals: in my own area for example (sperm
>function) H2O2 is highly toxic to sperm but at very low levels is now seen
>as a central messenger in the acrosome reaction-essential for
>fertilization.  I can supply refs if people are interested (not really
>relevant to this list).
 
The paper you are refering to might be:
 
"Nitric oxide formation during light-induced decomposition of
phenyl N-tert-butylnitrone"
 
  by CHAMULITRAT-W; JORDAN-S-J; MASON-R-P; SAITO-K; CUTLER-R-G
      Lab. Mol. Biophysics, National Inst. Environmental Health Sci., NIH,
      P.O. Box 12233, Research Triangle Park, NC 27709 USA
 
  in  JOURNAL OF BIOLOGICAL CHEMISTRY [1993] 268(16): 11520-11527
 
Regards,
Lou Pagnucco (lpagnucco at delphi.com)




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