deletions in MtDNA
Dr Jim Cummins
cummins at POSSUM.MURDOCH.EDU.AU
Wed Mar 1 19:48:58 EST 1995
Hi: J.Harvey at net.bio.net wrote
>Anyone out there working on deletions in MtDNA?
Yes, we are interested in mtDNA deletions as possible cause of male
infertility: some forms of which present as premature ageing of the testis.
See our recent review in Molecular Reproduction and Development 1994 37:
345-362. I'd be happy to continue to share ideas.
>I've got a question concerning the direct repeats flanking the
>regions that get deleted.
My understanding is that the major deletions occur in regions of tandem
repeats that cause slipped-strand misrepair during replication. See
Corral-Debrinski et al J A Med Assoc 266: 7952-6. However, I'm open to
Jim "Spermatology rules o~ o~ o~ o~" Cummins
Associate Professor in Veterinary Anatomy
Murdoch Western Australia 6150
Tel +61-9-360 2668
Fax +61-9-310 4144
E mail cummins at possum.murdoch.edu.au
"I hate quotations"
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