Coles and Harris' CoQ10 Study (was Re: A4M Discussion)

[Brian Manning Delaney]

In article <lulyD4pzK2.LJ2 at netcom.com> luly at netcom.com (Robert Luly) wrote, among other things:
>Hello Brian
>I was at that talk in Vegas and I got a copy of the slides from Dr. Coles.
> I heard Dr. Regelson say something similar when quoting a friend regarding
>DHEA replacement vs: natural reduction of hormone levels. That is maybe this 
>reduction *extends* life and should not be restored to youthful levels.

Exactly my concern.

> Regarding the Coles slides I noticed that the 80% to 20% survival slope was 
>about the same for controls and the test animals. The max survival was also
>the same. However *ALL* the CoQ-10 group was shifted to the right by 
>about 30 %. That looks like a positive effect to me. 

I'm not sure I follow you here "*ALL* .. shifted.."?

Anyway, on a diff. note, the survival curve diagram also shows nearly
identical results for folate (not discussed ina the paper).

[End of new material.]



>Regards
>R. Luly 
>
>Brian Manning Delaney (bmdelane at ellis.uchicago.edu) wrote:
>: In article <Pine.SOL.3.91.950227233436.28647A-100000 at corona>,
>: Patrick O'Neil  <patrick at corona> wrote:
>: >
>: >
>: >On Tue, 28 Feb 1995, Brian Manning Delaney wrote:
>: >> I thought this study was quite interesting. CoQ had no effect on max.
>: >> life span, but had a fairly significant effect on avg. life span
>: >> (experimental animals had about a 20% greater avg. life span).
>: >> Autopsies showed that cause of death was essentially the same for both
>: >> groups. The effect of CoQ was just to delay the onset of lymphoma. The
>: > 
>: >The CoQ you refer to...is it coenzyme Q?  If so, then perhaps the fact 
>: >that it is utilized in electron transport and ATP generation might help 
>: >explain greater physical activity (more efficient/proficient electron 
>: >transport?).  If you do not refer to coenzyme Q, then...nevermind.
>: >
>: >Would you clarify for me?
>
>: Yes, sorry, coenzyme Q10 is the drug/"nutrient" in question. I think
>: it's quite likely indeed that its role in ATP generation explains the
>: diff. levels of activity seen between the two groups. But my main
>: point was that "youthification" may not always mean a longer life
>: span, in part because the symptoms of aging could be protective in
>: some way. Ex: some (but not all) studies have shown declining levels
>: of CoQ w/age in rats. Maybe the slower metabolism this produces
>: actually slows aging (lower consequent rate of free-rad. production,
>: etc.).
>
-- 
Brian M. Delaney <b-delaney at uchicago.edu> [DO NOT cc: articles to me.]
<bmdelane at midway.uchicago.edu> [Wrists: "Leave unambiguous typos."]
Note: All statements in this article are in jest; they are not
statements of fact. * "Mein Genie ist in meinen Nuestern." -Nietzsche.