Werner's syndrome cause?

Jonathan Ewbank ewbank at monod.biol.mcgill.ca
Wed May 17 19:30:13 EST 1995

There have been threads on and off about Werner's syndrome, but no 
mention of it for a while. On the other hand, a number of papers have 
come out in the last year or so, each proposing a candidate for the 
causative mutations. Among the possibilities suggested are F1-ATPase, DNA 
polymerase and telomerase (references below). Have any of 
the possiblities been definitely eliminated? What does the current 
evidence point to? I'd be interested to hear any opinions.


  Oshima J.  Campisi J.  Tannock TC.  Martin GM.
  Regulation of c-fos expression in senescing Werner syndrome fibroblasts
  differs from that observed in senescing fibroblasts from normal donors.
  Journal of Cellular Physiology.  162(2):277-83, 1995 Feb.

  Kruk PA.  Rampino NJ.  Bohr VA.
  DNA damage and repair in telomeres: relation to aging.
  Proceedings of the National Academy of Sciences of the United States of
  America.  92(1):258-62, 1995 Jan 3.

  Kroll J.
  The mitochondrial F1-ATPase and the aging process.
  Medical Hypotheses.  42(6):395-6, 1994 Jun.

  Chang M.  Burmer GC.  Sweasy J.  Loeb LA.  Edelhoff S.  Disteche CM.  Yu
  CE.  Anderson L.  Oshima J.  Nakura J.  et al.
  Evidence against DNA polymerase beta as a candidate gene for Werner
  Human Genetics.  93(5):507-12, 1994 May.

  Sadakane Y.  Maeda K.  Kuroda Y.  Hori K.
  Identification of mutations in DNA polymerase beta mRNAs from patients
  with Werner syndrome.
  Biochemical & Biophysical Research Communications.  200(1):219-25, 1994

  Liu S.  Thweatt R.  Lumpkin CK Jr.  Goldstein S.
  Suppression of calcium-dependent membrane currents in human fibroblasts by
  replicative senescence and forced expression of a gene sequence 
  encoding a putative calcium-binding protein.
  Proceedings of the National Academy of Sciences of the United States of
  America.  91(6):2186-90, 1994 Mar 15

Jonathan Ewbank
Department of Biology                  ewbank at monod.biol.mcgill.ca
McGill University                      (514) 398 6278
1205 Dr Penfield Avenue                fax   398 5069
Montreal  PQ
Canada    H3A 1B1

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