Mark R. Miglarese
miglaresemr at pfizer.com
Wed Apr 3 12:09:52 EST 1996
Points to consider:
1. Human telomerase has not been cloned or purified yet. It is a huge
ribonucleoprotein complex (>800 kDa) which is very difficult to work
2. All issues concerning gene therapy apply (delivery etc.).
3. Most importantly, increased telomerase activity is associated with a
wide variety of tumors. In short, cells that live longer are more
likely to become transformed. In fact, telomerase is being actively
targeted by several labs in the hope of inhibiting tumor growth.
Upregulating it in normal cells would not be a good idea.
Mark R. Miglarese, Ph.D.
Pfizer Central Research
Eastern Point Road
Groton, CT USA 06340
Phone: (860) 441-8478
FAX: (860) 441-1290
Email: miglaresemr at pfizer.com
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