DHEA effects - could calorie restriction be a factor?

Brian Rowley browley at UNIXG.UBC.CA
Sun Aug 11 18:18:09 EST 1996

Yes, it is known that DHEA administration reduces intake in rodents. 
Another reference: Pasko LL, et al. Inhibition of proteinuria development
in aging Sprague-Dawley rats and C57BL/6 mice by long-term treatment with
dehydroepiandrosterone. Journal of Gerontology. 41(4):433-438, 1986.

In this study, DHEA reduced food intake by about 14%. I'm sure it must
depend on amount of DHEA given to the mice, though. 

	When the mice were pair fed, the DHEA group still gained less
weight than the controls, so DHEA in mice at least does still have weight
loss properties not related to dietary restriction. It increases body
temperature in rodents for example, so they burn off more heat.

	Other possible antiobesity mechanisms exist for DHEA in rodents as
well. DHEA increases liver peroxisomes, which are fat-burning engines
(fatty acids are broken down in peroxisomes to energy rich acetyl-CoA in a
process called beta-oxidation). However, DHEA does not increase liver 
peroxisomes in humans the way it does in mice, and the evidence for DHEA 
fat loss effects in humans is totally shakey and contradictory.

On 6 Aug 1996, Tim Freeman wrote:

> steve at lifeco.DIALix.oz.au (Steve Chambers) wrote:
> : I just came across the following:
> :  We recently observed that mice fed a diet containing DHEA ate ~30%
> :  less food than did mice on a control diet (Weindruch, 1984).
> :  
> : but haven't been able to find any confirmation amongst material I
> : have at hand.
> Does "confirmation" mean an independent reproduction of the same
> result, or an independently generated summary of the original
> research?
> The full reference is: Weindruch, R., McFeeters, G., and Walford,
> R.L.: Food intake reduction and immunologic alterations in mice fed
> dehydroepiandrosterone.  Exp Gerontol, 19:297, 1984.
> This is from the bibliography of The Retardation of Aging and Disease
> by Dietary Restriction by Weindruch and Walford.  The reference
> appeared on page 255:
> "A caveat here is that ad lib feeding of DHEA-containing diets has
> been found in other studies to reduce food intake (Nyce et al., 1984;
> Weindruch et al., 1984) perhaps because DHEA-containing diets are
> unpalatable (Gosnell, 1987)."
> I suppose the confirmation might be in the Nyce reference:
> Nyce, J.W., Magee, P.N., Hard, G.C., and Schwartz, A.: Inhibition of
> 1, 2-dimethylhydrazine-induced colon tumorigenesis in Balb/c mice by
> dehydroepiandrosterone.  Carcinogenesis, 5:57, 1984.
> I have not read any of these beyond The Retardation of Aging and
> Disease by Dietary Restriction.
> Posted and mailed.
> Tim Freeman

More information about the Ageing mailing list