DHEA effects - could calorie restriction be a factor?

Brian Rowley browley at UNIXG.UBC.CA
Tue Aug 13 22:43:57 EST 1996

There is a standard procedure called "pair-feeding" which is done to
compensate for things which suppress appetite, for example. If a given
amount of DHEA causes mice to eat 30% fewer calories, someone like Walford
or Weindruch would (a) find the weight of food consumed each day by the
DHEA mice (food eaten = food given - food remaining - food spilt) and (b)
feed the control mice exactly the same mass of food on a day to day basis.
In other words, restrict the control mice 30% also, by matching control
intake to DHEA intake. Mice must be of equivalent weights and age 

	Incidentally, Arthur Schwartz didn't document appetite suppressant
effects of DHEA in his initial papers--as I recall he fed the mice via a
tube, so it was just pumped into their guts. -cheers

On 12 Aug 1996, Charles Carter wrote:

> >steve at lifeco.DIALix.oz.au (Steve Chambers) wrote:
> >: I just came across the following:
> >
> >:  We recently observed that mice fed a diet containing DHEA ate ~30%
> >:  less food than did mice on a control diet (Weindruch, 1984).
> >
> >
> >Tim Freeman
> Perhaps someone should repeat the study and administer ~30% more calories 
> to the DHEA mice, to make sure that the anti-aging effects of DHEA can't 
> be attributed to the caloric restriction (as Tim pointed out).
> Chuck

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