b.neilan at unsw.edu.au
Mon Jan 15 22:33:38 EST 1996
Does anybody know if the hypothesis that exogenous antioxidants causes a
down regulation of the endogenous oxidative damage repair pathways has
been tested? I guess it would be possible to look at the expression of
various repair enzymes by protein/reporter fusions, Northerns, Quant mRNA
PCR, etc. This hypothesis would explain why antioxidant therapy has been
such a disappointment, except in those system where there is no endogenous
repair system ie. LDL oxidation prevention by Vitamin E.
School of Microbiology & Immunology
University of NSW
'I'm sorry but I don't have a pithy quote'
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