Antioxidant hyphothesis

[Daniel Jacobs]

Does anybody know if the hypothesis that exogenous antioxidants causes a
down regulation of the endogenous oxidative damage repair pathways has
been tested? I guess it would be possible to look at the expression of
various repair enzymes by protein/reporter fusions, Northerns, Quant mRNA
PCR, etc. This hypothesis would explain why antioxidant therapy has been
such a disappointment, except in those system where there is no endogenous
repair system ie. LDL oxidation prevention by  Vitamin E.

-- 
Daniel Jacobs
School of Microbiology & Immunology
University of NSW

'I'm sorry but I don't have a pithy quote'