Mitochondria oxidative damage?

Lou Pagnucco lpagnucco at delphi.com
Sat Jul 20 23:59:23 EST 1996


David Cassarino <dsc9w at avery.med.Virginia.EDU> writes:
 
>As neurons are teminally differentiated, their aging and death
>must involve mechanisms other than telomere loss.  As the brain
>is highly sensitive to oxidative damage and has relatively
>lower levels of free-radical scavenging enzymes than other
>tissues, mitochondrial dysfunction producing high amounts of
>free radicals and hence damage and aging in the brain is very
>plausible.  It has already been demonstrated conclusively that
 
Given the large body of research implicating mitochondrial free-
radicals in the aging process, it seems reasonable to try to slow
these damaging effects with anti-oxidants.  Several papers accessible
thru Medline contend that tocotrienols appear to retard the aging
of the brain in lab animals.  If these results are valid, then toco-
trienols must have some affinity for mitochondrial membranes.  Does
anyone know which anti-oxidants are most likely to actually quench
mitochondrial free-radicals within the mitochondrion?




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