longevity in C. elegans 2

Brian Rowley BRowley at ALUMNI.UBC.CA
Tue Aug 26 15:06:14 EST 1997


Vladimir V. Bakaev <vlad at bakaev.nsk.ru> wrote:
>In my previos experiment,  which see partly below, I found, that lowe-
>ring of temperature to +4oC increased longevity in _adult_  nematodes.
>I  discussed stidy I lowered temperature during _larval_ period of de-
>velopment, which not increased longevity. I cannot explain such pheno-
>men.

Dear Dr. Bakaev:
Thank you for your response. It is interesting that lowering temperature to
4 degrees C during adult but not larval stage extends longevity. This work
might have some analogy to that obtained in annual fish. The reference is:

Liu, RK and Walford RL. Mid-life temperature-transfer effects on life-span
of annual fish. Journal of Gerontology 30 (2): 129-131, 1975.

It was found that the longevity-enhancing effect of reduced temperature was
most effective during the latter part of the life span, least effective
during the early part of the life span. (The caloric restriction (CR) effect
is opposite; CR delays mortality most strongly when introduced early in the
life span.) In your study as with annual fish, temperature reduction seems
to delay mortality most strongly late in the life span.

>It can be concluded that such intermittent temperature is not
>able to prolong the life-span of C. elegans significantly, in
>comparison with constant cold,  as well as fecundity.

This is interesting. Thank you,

Brian Rowley





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