Sheep stuff...

mjfasmb mjfasmb at fs1.ce.umist.ac.uk
Mon Mar 24 15:53:03 EST 1997


> Hi Brian,
 
> >         Your arguments make a lot of sense. I'd like to know, though, were
> > Dolly's telomeres (or Hayflick divisions) restored to those of a newborn
> > lamb? It would be easy to find that out; just compare number of remaining
> > divisions (and length of telomeres) of sheep progenitor with that of lamb
> > clone. If the telomeres and remaining divisions were restored by cloning
> > that would imply that rejuvenation of adult cells is possible.
> > Brian Rowley
> 
> Interesting question.  I sincerely hope someone is 
> planning / attempting to find out how many P.D. Dolly's cells are 
> capable of.  The length of her telomeres would be easy enough to 
> ascertain.  Don't know if  Dolly's `mother' is still alive, or 
> whether tissue samples taken at the same time as the `Dolly-biopsy' 
> were frozen, but if would be nice to find out if there is a 
> difference in telomere length between mother and clone cells.
> 
> My guess is that in response to some maternal factor, or as a result 
> of manipulations to Dolly's original adult nucleus, some basal 
> embryonic expression pattern was re-established - including 
> expression of telomerase.  There does appear to be a telomere length 
monitoring pathway (recent Nature paper) in cells capable of 
expressing telomerase  - I imagine it would correct for any 
shortening detected...
> (?)
> MGB 




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