SOD and Downe's Syndrome

Aubrey de Grey ag24 at
Fri Aug 21 10:23:17 EST 1998

Cathy Woodgold wrote:

> It's my understanding that the main problem with Downe's Syndrome
> is too much SOD, therefore too much of the free radicals that are
> created by SOD when breaking down other free radicals.

That certainly has been the common view, and I believe it still is.

> Might it be feasible to treat Downe's Syndrome by putting more of the
> latter type of enzyme into the person, perhaps by daily injections?
> (Or by consuming the nutrients needed for that enzyme (selenium??))

Some studies have been done on this -- a search in Medline using the
string "down's syndrome catalase" works quite well.  I don't know any
more, but I also found a reference (Int J Dev Biol 1989;33(1):183-188)
which notes that glutathione peroxidase (the other hydrogen peroxide
destroying enzyme) is not upregulated in response.  The abstract doesn't
give any theory why not, though.

> If we can find effective treatments for Downe's Syndrome, it
> might help us find anti-ageing treatments for everyone.

Quite possibly.  I will look up the above paper and others and maybe
post something more illuminating in due course.  Thanks for the idea.

Aubrey de Grey

More information about the Ageing mailing list