excelife at earthlink.net
Sat Dec 19 00:01:24 EST 1998
Dr. H.L. Sweeney of University of Pennsylvania, School of Medicine,
Philadelphia, Pa. has publicized research wherein viral vectors can deliver
IGF-1, (Insulin like growth factor), into the muscles of elderly rats. He
states that these mice regained 27% of muscle mass lost with age. Younger
mice re-gained 15% of muscle mass.(note: the news articles and Medline did
not turn up the cite so if anyone knows it please let me know.)
Vergani L, et.al. in J Neurosci Res 1998 Dec 15;54(6):840-7 "Systemic
administration of insulin-like growth factor decreases motor neuron cell
death and promotes muscle reinnervation." shows that IGF-1 also restores
motor neuron functioning in these muscles.
If these results are applicable to humans then this is a major advance in
Telomeric lengthening can have the effect of extending the replicative life
span of cellular systems that normally reproduce but would have little effect
on the satellite cells that can restore muscle cells lost over time.
These findings on IGF-1 show that it can cause these satellite cells to
restore some muscle functions in elderly rats and may help avoid some of the
more debilitating stages of aging. In conjunction with telomeric therapy two
major hurdles to longevity appear to be resolved.
The last major challenge remains the restoration of the functioning of the
central nervous system in an elderly population.
Thomas Mahoney, Pres.
Lifeline Laboratories, Inc.
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