Telomerase Expression in Human Cells!

stollman at stollman at
Thu Dec 31 20:03:44 EST 1998

On Thu, 31 Dec 1998  "M. Prakash Hande" <phande at> wrote:

>Very interesting and unbelievable. The same cell lines were used by these
>two groups funded by the same company. Is presence of 6 to 7 % cytogenetic
>abnormalities (among them translocation, tetraploid cells and telomere
>associations) considered as normal karyotype? If so, why billions of dollars
>are spent to understand one translocation or one mutation or one abnormality
>which has minimal impact on human health according to these papers.
>>Geron Announces First In Vivo Data Indicating Telomerase Expression in
>>Normal Human Cells Extends Their Replicative Lifespan Without Oncogenic
>I am lost here, what is the definition of IN VIVO in those two papers?

The Chief Geron Scientist was told that he has to wait a year to be
admitted to kindergarten :-)

This is what a press release says:

The long-term forced expression of telomerase by human cells grown in
laboratory culture dishes did not result in any of the changes typically
associated with cancer cells. The cells did not develop chromosome
abnormalities or lose contact inhibition, a normal process in which
cells stop growing when they come into contact with other cells.

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