news ideas

Rodney Reid rreid at earth.execpc.com
Sat Feb 28 17:14:32 EST 1998


Vladimir V. Bakaev (vlad at bakaev.nsk.ru) wrote:
: I'm looking  for  any  scientific extraordinarily unusual ideas and methods
: for prolonging life-span.  I'm going to investigate these ideas and methods
: on the nematode Caenorhabditis elegans. Any suggestions?
: Thanks,
: Bakaev V.V.
: RUSSIA, 630107, Novosibirsk, box 45
: e-mail: vlad at bakaev.nsk.ru

Subject: Re: news ideas
Newsgroups: bionet.molbio.ageing
References: <6d7v1c$o0c at mserv1.dl.ac.uk>
Organization: Exec-PC Internet
Distribution: bionet


Hi Vladimir,

	Sounds interesting.   Here are  number of unusual ways of
(possibly) prolonging lifespan that haven't been fully investigated, which
I will explain below:

	(1)	RNA/DNA (nucleic acid) supplementation
	(2)	Increasing length of circadian cycle
	(3)	Mica binding to DNA, as a protectant?
	(4)	Chinese patent formula "ren-shen-yang-rong-tang"


(1) Nucleic acid supplementation

Here's a study that seems really interesting, and as far as I know has
never been attempted again:

Odens, Max. Prolongation of the life span in rats. Journal of the American
Geriatrics Society. 21(10): 450-451. October 1973.

"To test the effect of RNA-DNA in preventing the deleterious effects of
old age, an experiment was conducted that involved 10 rats with a normal
life span of 800-900 days. All were fed the same diet; 5 rats were not
treated, and 5 were given weekly injections of DNA + RNA. After twelve
weeks the difference in appearance, weight and alertness was remarkable.
The 5 untreated rats died before 900 days. Of the treated rats, 4 died at
ages of 1600-1900 days, and 1 at 2250 days. A parallel cannot be drawn
with aging in human beings fed RNA-DNA, but the findings on rats may have
some application to cellular studies on cancer."

...You may want to link to the longevity digest's old topics page at:
	http://www.interchange.ubc.ca/browley/archive.html



(2) Increasing length of circadian cycle

This is just a hunch, but since it seemed to hasten death in rats when a
short seasonal cycle was used.  Possibly a longer day night (with maybe
artificial seasonal influences in temp, lux, sunrise/sunset times, etc.)
would trick the nematodes growth cycle?    Sorry I can't find the rat
study for you.



(3) DNA to Mica binding as a protectant of DNA(?)

Another hunch.  Chemically modified mica has been mentioned again and
again in ancient Chinese, Indian, and Tibetan medical texts as a longevity
agent.  Research from the early 1990s started coming out that Mica could
bind tight enough to DNA to allow it to be imaged with scanning tunneling
microscopes, and the addition of certain metal ions to the mix stopped the
supercoiling that was happening when bonding with just straight Mica.
Here's a link to dejanews to an article I wrote a while back on this,
although to my knowledge no one has scientifically tried this on living
cells yet:     http://x3.dejanews.com/getdoc.xp?AN=217970037

See if you can get your hands on any traditional formulas of mica, either
Indian ("Abhrak Bhasma") or Tibetan.   Likely there are going to be hugely
expensive, as the traditional texts call for years of daily preparation
before it's ready for use.   Try finding an address for the newly opened
Astro-Medical Centre, Lhasa, Tibet and ask them about it.




(4) Chinese patent formula "ren-shen-yang-rong-tang"

Now that I think about it, most of the Japanese done research (their name
for it is Ninjinyoeito) shows this collection of herbs to increase
lifespan in Werner's Syndrome skin cells which wouldn't affect nematodes
as they don't have dividing cells once they hit adulthood right?  See:

Am J Chin Med 1992;20(3-4):295-305 
The effect of Ninjinyoeito on Werner's syndrome skin fibroblasts.
Uchiyama Y, Nakajima S, Ohno T, Goto M, Kan M, Haruki E

"The effect of Ninjinyoeito on three cases of Werner's syndrome
fibroblasts was investigated. In all three cases, groups which were
treated with Ninjinyoeito showed improved life-span doubling levels
compared to groups which were not treated with Ninjinyoeito. Also, all of
the treated group in all three cases showed significantly higher values in
the rates of DNA synthesis including two cases which showed significantly
higher rates of protein synthesis."



	Please let us know about your research results.

	...Rodney





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