Re-Visiting a Post by Lou Pagnucco
james at nospam.com
Fri Oct 23 11:37:04 EST 1998
> A weaker link in Lou's idea is the question of whether these senescent
> fibroblasts are responsible for lax skin etc. It is unclear whether
> the overproduction of collagenase would have these effects, since they
> are normally ascribed to the disorderly crosslinking of OLD collagen.
> Most such collagen should be no less degradable by collagenase than
> undamaged collagen, so this overproduction may, if anything, actually
> RETARD these features of aging of skin.
I would agree with this 100% - if collagenase were the only
factor. But I don't think lax skin has much to do with collagen
crosslinking (other than some decreased elasticity). I think
loss of subcutaneous fat is the culprit here. I don't know why
that happens - is it a general hormonal change, or something to
do with fibroblasts?
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