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Telomerase activity in "immortal" fish. (FWD)

T. Benjamin Csoka csoka at ITSA.UCSF.EDU
Wed Sep 23 17:24:48 EST 1998

> FEBS Lett 1998 Sep 4;434(3):409-412
> Telomerase activity in 'immortal' fish.
> Klapper W, Heidorn K, Kuhne K, Parwaresch R, Krupp G
> Institute for Hematopathology, Center for Pathology and Applied Cancer Research, Christian-Albrechts-Universitat Kiel, Germany.
> [Medline record in process]
> Eukaryotic chromosome termini consist of telomeres, short sequence repeats. According to the telomere hypothesis, DNA replication leads
> to telomere shortening, resulting in a cellular mitotic clock. Telomerase resets it by telomere synthesis. In mammals with a limited growth
> phase, telomerase activity in somatic tissues is restricted to stem cell derivatives with high proliferation potential. But other animals, like
> some fish, grow throughout their life with little senescence. All somatic cells require a high proliferation capacity and telomerase should be
> active in all cells, irrespective of fish age. Indeed, we detected high telomerase activities in all analyzed organs of rainbow trout
> (Oncorhynchus mykiss).

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