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FW: Telomerase activity in "immortal" fish. (FWD)

Michael Sherrell grizzly at SLIP.NET
Wed Sep 23 20:37:48 EST 1998

Fine; how do we get telomerase into our cells?

Mike Sherrell
Grizzly Analytical

-----Original Message-----
From:	"T. Benjamin Csoka" [SMTP:csoka at ITSA.UCSF.EDU]
Sent:	Wednesday, September 23, 1998 3:25 PM
To:	ageing at net.bio.net
Subject:	Telomerase activity in "immortal" fish. (FWD)

> FEBS Lett 1998 Sep 4;434(3):409-412
> Telomerase activity in 'immortal' fish.
> Klapper W, Heidorn K, Kuhne K, Parwaresch R, Krupp G
> Institute for Hematopathology, Center for Pathology and Applied Cancer Research, Christian-Albrechts-Universitat Kiel, Germany.
> [Medline record in process]
> Eukaryotic chromosome termini consist of telomeres, short sequence repeats. According to the telomere hypothesis, DNA replication leads
> to telomere shortening, resulting in a cellular mitotic clock. Telomerase resets it by telomere synthesis. In mammals with a limited growth
> phase, telomerase activity in somatic tissues is restricted to stem cell derivatives with high proliferation potential. But other animals, like
> some fish, grow throughout their life with little senescence. All somatic cells require a high proliferation capacity and telomerase should be
> active in all cells, irrespective of fish age. Indeed, we detected high telomerase activities in all analyzed organs of rainbow trout
> (Oncorhynchus mykiss).

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