Fine; how do we get telomerase into our cells?
From: "T. Benjamin Csoka" [SMTP:csoka at ITSA.UCSF.EDU]
Sent: Wednesday, September 23, 1998 3:25 PM
To: ageing at net.bio.net
Subject: Telomerase activity in "immortal" fish. (FWD)
> FEBS Lett 1998 Sep 4;434(3):409-412
>> Telomerase activity in 'immortal' fish.
>> Klapper W, Heidorn K, Kuhne K, Parwaresch R, Krupp G
>> Institute for Hematopathology, Center for Pathology and Applied Cancer Research, Christian-Albrechts-Universitat Kiel, Germany.
>> [Medline record in process]
>> Eukaryotic chromosome termini consist of telomeres, short sequence repeats. According to the telomere hypothesis, DNA replication leads
> to telomere shortening, resulting in a cellular mitotic clock. Telomerase resets it by telomere synthesis. In mammals with a limited growth
> phase, telomerase activity in somatic tissues is restricted to stem cell derivatives with high proliferation potential. But other animals, like
> some fish, grow throughout their life with little senescence. All somatic cells require a high proliferation capacity and telomerase should be
> active in all cells, irrespective of fish age. Indeed, we detected high telomerase activities in all analyzed organs of rainbow trout
> (Oncorhynchus mykiss).