Telomeric Theory - Growth Factors

Olaf Henny olafh at direct.ca
Wed Sep 30 00:06:52 EST 1998


>Just some wild speculation here -
>
>An opinion I have read is that increased lifespan under CR may be a way of an
>organism making the "best of a bad lot" when conditions are so bad that it
>would be unlikely that offspring would survive. Extending life until
>conditions improved may be a strategy that has evolved that optimises
>reproductive fitness under difficult conditions.

This would jibe with the observation, that CR started in older mice
(in post-reproductive age) does not have a life-prolonging effect.

Best,
Olaf
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Tolerance is wisdom's finest fruit
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