Telomeric Theory - Growth Factors

Tom Matthews tmatth at netcom.ca
Wed Sep 30 00:43:58 EST 1998


Olaf Henny wrote:
> 
> >Just some wild speculation here -
> >
> >An opinion I have read is that increased lifespan under CR may be a way of an
> >organism making the "best of a bad lot" when conditions are so bad that it
> >would be unlikely that offspring would survive. Extending life until
> >conditions improved may be a strategy that has evolved that optimises
> >reproductive fitness under difficult conditions.
> 
> This would jibe with the observation, that CR started in older mice
> (in post-reproductive age) does not have a life-prolonging effect.

But it *does*, Olaf! even when started in late-life. Although it is far
less than when started younger and is even less than a linear
relationship with age would imply.

--Tom 
Tom Matthews
 
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