Telomerase Expression in Human Cells!

Brian Manning Delaney bmdelaney at infinitefaculty.org
Sat Jan 2 14:34:13 EST 1999


Thomas Mahoney <Excelife> wrote:

> I lost a few brain cells last night due to the
> effects of a few bubbles in a glass but let me
> see if I can straighten out some of the
> confusion in regards to Gerons recent
> announcement, which Tom was so thoughtful in
> providing.

(It's only the weakest brain cells that die, so you're now leaner
and meaner. At least that's what I was telling myself the other
night. Although by 4 A.M., some not so weak ones were biting the
dust too, I fear.... Thank God my cloned neurons are almost ready
to harvest. :)

> Although the complete paper is not yet available,
> (and I was hoping to wait for its publication
> before responding), it seems that they are
> merely saying that the cells transfected with
> telomerase in their Science 1998 Jan 16;279(5349):349-352
> article are still reproducing in a
> phenotypically normal state.

Yes, exactly. Not that this isn't exciting news (though rumors to
this effect have been circulating for a while).

> They do, however, seem to be foreshadowing a
> future announcement with their  references to "in
> vivo" determinations.

The announcement won't be in the future, but rather in an
accompanying article, according to the press release here:
http://irweb.swmed.edu/newspub/newsdetl.asp?story_id=95

(Though maybe you're thinking of a different in vivo
demonstration/experiment.)

A good "horse's mouth" source is the Shay/Wright lab Web page:
http://www.swmed.edu/home_pages/cellbio/shay/

May we all be well through this next year (and beyond!),
Brian.
--
Brian Manning Delaney
email = first initial + hyphen + last name at uchicago.edu
SANCTUS JANUARIUS.
Zum neuen Jahre. - Noch lebe ich, noch denke ich:
ich muss noch leben, denn ich muss noch denken.
Sum, ergo cogito: cogito, ergo sum. -Nietzsche.




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