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Are AGEs and Lipofuscin related? Could ALT-711 eliminate lipofuscin?

Aubrey de Grey ag24 at mole.bio.cam.ac.uk
Wed Jan 6 17:51:18 EST 1999

William wrote:

> I have read on
> many different websites that age/liver spots are caused by an
> accumilation of Advanced Glycation End-Products and their resulting
> Crosslinks.

I think that's wrong too.  Where did you read it?

> perhaps all the theories of "eventual aging", that have at least
> some merit, could be put together and accumilated into one theory of
> "immediate aging". 

That's a popular (I mean among experts) and reasonable view.  Might be
right, might not.

> in my opinion telomere
> shortening "might", from what I have read, be the cause of most of
> these various theories of "eventual aging"

That's a much less popular (I again mean among experts) view, but it
can't be conclusively rejected quite yet.

> Did it increase their average life span?

Yes, fewer early deaths.  The abstract is on Medline; hit its "Related
Articles" too for others that may interest you.

Aubrey de Grey

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