Are AGEs and Lipofuscin related? Could ALT-711 eliminate lipofuscin?
baker_joshua at hotmail.com
baker_joshua at hotmail.com
Wed Jan 20 09:26:09 EST 1999
This post contains information on chemicals I have never heard of and I
like that. It also has an obvious omission dimeythalaminoethynol d.m.a.e the
substance cited most often in popular smart drug culture as removing age
pigment, if taken continously for A FEW YEARS. Lucidril is
dimeythalaminoethynol and chlorphenoxyacetcacid. This second compound being
a plant nerve growth hormone. What has phenteramine got to do with LUCIDRIL
does chlorphenoxyaceticacid metabolise into phenteramine? If it does I would
sure like to know, I'm onto my twentieth continual month of Lucidril. How
can you take a few lucidril jump on an exercise bike and say it "doesn't
work", when it needs to be taken for a few years? I have seen many anecdotes
from people who having done this have watched their age spots fade and
vanish. I have seen more citations than nadys about the benifits of Lucidril
and more even on d.m.a.e. which is ment to work better when taken as
In article <77qr1m$vbp$1 at nnrp1.dejanews.com>,
rjk3 at my-dejanews.com wrote:
> In article <369d8fda.150194757 at nntp.ix.netcom.com>,
> ufotruth at ix.netcom.com wrote:
> > Everyone,
> > I just wanted to let all of you know that I emailed Alteon and asked
> > them about ALT-711's effects on lipofuscin. They told me that they
> > have done no research into any effects of ALT-711 on lipofuscin.
> > Best Regards,
> > William
> More on spin traps, lipofuscin and age breakers....
> PBN (phenyl butyl nitrone) was reported in the early 90's to remove
> lipofuscin deposits from the cells of aged mice, and was theorized to thereby
> improve mitochondrial efficiency, as evinced in the performance of aged rats
> in swim-to- exhaustion tests. Trials in humans were apparently
> disappointing, though. (Can anyone amplify on this? I know the NIH was
> conducting human trials, but know nothing of the outcome.)
> Centrophenoxine (Lucidril) has been reported by Nandy to remove lipofuscin
> deposits from cells, but I do not believe his work has been confirmed
> elsewhere. I obtained some in Spain. It did not have any noticeable effects
> on my endurance. (I used a bicycle ergonometer, lab-accurate wattage
> measurements.) I found (from the package insert) that one of
> Centrophenoxine's breakdown products is an amphetamine-like compound,
> (phenteramine? if I recall, which is itself a stimulant), that can cause
> athletes to test positive for amphetamines. I suspect this is also
> responsible for most of the reported effects of this substance. I don't
> think one would want to take something chronically that produces amphetamine
> alalogues in the body; I expect it would destroy neurons in the hipocampus.
> Angelo Schoeten (a chemist who used to hang out in this group) hypothesized
> that ethoxyquin, a synthetic anti-oxidant used in chicken feed and dog food,
> might produce spin trapping products in the body with an effect similar to
> PBN. I have no wish to try it, for I am not certain it would be without
> undesired side effects on the liver. Some of those who frequent these pages
> have tried ethoxyquin and might care to comment on its effects.
> Sage, and to a lesser extent thyme, have been reported to at least inhibit
> lipofuscin formation, if not prevent it. Sage tea, anyone?
> Vitamin B1 (thiamine) helps to prevent AGE formation. Perhaps in large doses,
> or in certain forms, it can act as an AGE breaker. A solution of thiaminn,
> applied to the skin, seems to reverse some of the effects of aging, at least
> in my experience: exfoliation, reduced wrinkles, smoother, thicker skin.
> The Alteon patent mentions several other compounds that have significant AGE-
> breaking qualities, though not as marked as ALT-711. Several are available in
> chemical supply catalogs. The only toxicity data I found was "may cause skin
> irritation." Good enough to try on mice or fruit flies.
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