Are AGEs and Lipofuscin related? Could ALT-711 eliminate lipofuscin?

baker_joshua at hotmail.com baker_joshua at hotmail.com
Wed Jan 20 09:26:09 EST 1999


  This post contains information on chemicals I have never heard of and I
like that.  It also has an obvious omission dimeythalaminoethynol d.m.a.e the
substance cited most often in popular smart drug culture as removing age
pigment, if taken continously for A FEW YEARS.	Lucidril is
dimeythalaminoethynol and chlorphenoxyacetcacid.  This second compound being
a plant nerve growth hormone.  What has phenteramine got to do with LUCIDRIL
does chlorphenoxyaceticacid metabolise into phenteramine?  If it does I would
sure like to know, I'm onto my twentieth continual month of Lucidril.  How
can you take a few lucidril jump on an exercise bike and say it "doesn't
work", when it needs to be taken for a few years?  I have seen many anecdotes
from people who having done this have watched their age spots fade and
vanish.  I have seen more citations than nadys about the benifits of Lucidril
and more even on d.m.a.e. which is ment to work better when taken as
lucidril.  Josh.















In article <77qr1m$vbp$1 at nnrp1.dejanews.com>,



  rjk3 at my-dejanews.com wrote:



> In article <369d8fda.150194757 at nntp.ix.netcom.com>,



>   ufotruth at ix.netcom.com wrote:



> > Everyone,



> >



> > I just wanted to let all of you know that I emailed Alteon and asked



> > them about ALT-711's effects on lipofuscin. They told me that they



> > have done no research into any effects of ALT-711 on lipofuscin.



> >



> > Best Regards,



> > William



> >



>



> More on spin traps, lipofuscin and age breakers....



>



> PBN (phenyl butyl nitrone) was reported in the	early 90's to remove



> lipofuscin deposits from the cells of aged mice, and was theorized to thereby



> improve mitochondrial efficiency, as evinced in the performance of aged rats



> in swim-to- exhaustion tests.  Trials in humans were apparently



> disappointing, though. (Can anyone amplify on this?  I know the NIH was



> conducting human trials, but know nothing of the outcome.)



>



> Centrophenoxine (Lucidril) has been reported by Nandy to remove lipofuscin



> deposits from cells, but I do not believe his work has been confirmed



> elsewhere.  I obtained some in Spain.  It did not have any noticeable effects



> on my endurance.  (I used a bicycle ergonometer, lab-accurate wattage



> measurements.) I found (from the package insert) that one of



> Centrophenoxine's breakdown products is an amphetamine-like  compound,



> (phenteramine? if I recall, which is itself a stimulant),  that can cause



> athletes to test positive for amphetamines.  I suspect this is also



> responsible for most of the reported effects of this substance.  I don't



> think one would want to take something chronically that produces amphetamine



> alalogues in the body;	I expect it would destroy neurons in the hipocampus.



>



> Angelo Schoeten (a chemist who used to hang out in this group) hypothesized



> that ethoxyquin, a synthetic anti-oxidant used in chicken feed and dog food,



> might produce spin trapping products in the body with an effect similar to



> PBN.  I have no wish to try it, for I am not certain it would be without



> undesired side effects on the liver.  Some of those who frequent these pages



> have tried ethoxyquin and might care to comment on its effects.



>



> Sage, and to a lesser extent thyme, have been reported to at least inhibit



> lipofuscin formation, if not prevent it.  Sage tea, anyone?



>



> Vitamin B1 (thiamine) helps to prevent AGE formation.  Perhaps in large doses,



> or in certain forms, it can act as an AGE breaker.  A solution of thiaminn,



> applied to  the skin, seems to reverse some of the effects of aging, at least



> in my experience: exfoliation, reduced wrinkles, smoother, thicker skin.



>



> The Alteon patent mentions several other compounds that have significant AGE-



> breaking qualities, though not as marked as ALT-711.  Several are available in



> chemical supply catalogs.  The only toxicity data I found was "may cause skin



> irritation."   Good enough to try on mice or fruit flies.



>



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