Are AGEs and Lipofuscin related? Could ALT-711 eliminate lipofuscin?

Alf Christophersen alf.christophersen at basalmed.uio.no
Wed Jan 27 16:45:16 EST 1999


alf.christophersen at basalmed.uio.no (Alf Christophersen) wrote:

>Michael Sierchio <kudzu at dnai.com> wrote:
>
>>Oh, puhleeze.  Of course there are problems with ethoxyquin -- it's
>>an agbiz chemical used to replace the much more expensive Vit. E in
>>chicken feed, for e.g.  Most manufacturers of mammal chows have stopped
>>using it -- but it isn't a fungicide,  it's an antioxidant.
>
>In fishmeal production it is used as both. Interestingly enough.
>
>It is used as an antioxidant, but under some conditions, it is a strong
>oxidant.
>

Sorry, a colleague has mislead me. It is only used as an antioxidant.

In vivo it produces superoxide anion radical, just as paraquat does, but
by another mechanism. The big difference btw. paraquat and ethoxyquin is
that paraquat is water soluble and if you survive, the toxic effect will
diminish after a few days. Ethoxyquin on the other hand is fat soluble,
and the intoxication may continue for a year or more. 

My brother said to me that he had good effects of high doses of
ubiquinone, vit E, taurine and selenium (only ubiquinone is needed in
very high dosis because it is poorly absorbed by intestines. Some of
colleagues state it is not absorbed at all, but I have pesonally seen my
brother having a dangerous attack and being relieved about 30 min to 1
hour after taking ubiquinone. But I agree with my colleagues that the
effects may be outside the mitochondria (there are some reports about an
ancient electron transport system working in RER area and Golgi
apparatus where ubiquinone has a role as electron transporter)





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