CANCER CELL/TISSUE RESPIRATION IN CULTURE

Paul S. Brookes. brookes at uab.edu
Thu Mar 11 18:40:57 EST 1999


Is this really very exciting?  It has been known for quite some time that
transformed cells possess a much greater glycolytic potential, and less
mitochondria than their "normal" counterparts.  In fact this is one of the
main criticisms of the use of cultured cell lines in any kind of research
in which the biological effect may be mitochondrially mediated. (e.g. you
can expose cultured endothelial cells to lots of nitric oxide and it
doesn't affect their ATP levels).

Just a small point really
PSB


______________________________________________
Dr. Paul S. Brookes.         (brookes at uab.edu)
UAB Department of Pathology,  G004 Volker Hall
1670 University Blvd., Birmingham AL 35294 USA
Tel (001) 205 934 1915  Fax (001) 205 934 1775
http://peir.path.uab.edu/brookes





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