mitochondrial DNA - all things bad?
tmatth at netcom.ca
Mon Nov 15 08:53:00 EST 1999
Aubrey de Grey wrote:
> Doug Skrecky wrote:
> > Title
> > Mitochondrial DNA--all things bad?. [Review] [27 refs]
> > Source
> > Trends in Genetics. 15(3):91-3, 1999 Mar.
> > The mitochondrial theory of ageing, however attractive in principle,
> > is supported by very little hard evidence.
> Yes, an excellent review (and I say that not just because I know the
> authors well). It highlights the shortcomings (i.e. incompatibility
> with existing data) of the simplistic mitochondrial theory of aging,
> which is that we lose bioenergetic capacity due to having fewer and
> fewer functional mitochondrial genomes. That theory has been history
> for several years, in fact, and the somewhat frustrated tone of that
> review is a reflection of the reluctance to abandon it that some who
> should know better have shown. What the review doesn't cover is the
> considerably greater difficulties facing the idea that mitochondrial
> decline does NOT have much to do with aging. It does, however, note
> in conclusion that:
> "the argument that accumulation of mtDNA defects contributes to the
> ageing process is unconvincing, unless one postulates a wholly
> unprecedented 'dominant' effect of a small number of respiratory-
> deficient cells. Although an interesting hypothesis has recently
> proposed how such cells may cause a more global defect resulting
> in tissue senescence, this hypothesis has yet to be tested
> but modesty forbids me from elaborating.
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