private at private.com
Thu Nov 18 12:57:52 EST 1999
Hi, I just have some simple questions on this. I am not an expert but
I am really interested in the field and plan on reading the article.
However, there are some question I need answer so that I can
what does the p stand for in p66shc? does it mean protein?
> We show that: (1) p66shc is serine phosphorylated upon treatment with
>hydrogen peroxide (H2O2) or irradiation with ultraviolet light;
does that mean the serine phosphorylase is promoting or blocking
p66shc? is this good or bad for extending life span?
>(2) ablation of p66shc enhances cellular resistance to apoptosis induced
>by H2O2 or ultraviolet light;
I thought apotosis was good for getting rid of damaged cells? How
would resisting apotosis extend life span?
>(3) a serine-phosphorylation defective mutant of p66shc cannot restore
>the normal stress response in p66shc-/- cells;
Is the normal stress response good or bad for extending life span?
>(4) the p53 and p21 stress response is impaired in p66shc-/- cells;
I thought these mice had improved stress response?
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