MFRTA & the Ca Hypoth

Aubrey de Grey ag24 at
Fri Nov 26 12:44:42 EST 1999

Bob Walsh wrote:

> The paper's hypothesis was that accumulated oxidative damage in
> mitochondria causes increased resting free calcium concentrations.
> Because cells with damaged mitochondria show up as a mosaic pattern
> in other postmitotic tissue, whereas the increased resting Ca is
> more general, I concluded that the hypothesis was false.

Seems sound to me.  The mosaic pattern has been seen in the brain too:
see Itoh et al, Neurobiol Aging 17(6):843-848

Aubrey de Grey

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