MFRTA & the Ca Hypoth

Paul S. Brookes. brookes at uab.edu
Tue Nov 30 14:01:05 EST 1999


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Jim Cummins' comments regarding oocyte mtDNA may be related to another 
hypothesis - namely the reasoning behind inheritance of mtDNA from the 
maternal gamete, and the reason why sperm swim and eggs remain still.

It goes something like this......  If both gametes were motile, then both 
would require ATP presumably from mitochondria, and this would carry with 
it an associated level of mtDNA damage.  By keeping one gamete stationary 
(the egg), and then sacrificing the mtDNA of the motile one (the sperm), 
the integrity of mtDNA in the progeny is maintained.  Of course, this would 
all go to pot if the maternal mtDNA were mutated to begin with, so maybe 
there is some kind of index of mtDNA integrity (such as respiratory 
function/Ca handling) upon which oocytes are selected?

Paul


_________________________________________
Dr. Paul S. Brookes.            (brookes at uab.edu)
UAB Department of Pathology,   G004 Volker Hall
1670 University Blvd., Birmingham AL 35294 USA
Tel (001) 205 934 1915     Fax (001) 205 934 1775
http://peir.path.uab.edu/brookes

The quality of e-mails can go down as well as up

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<html><div>Jim Cummins' comments regarding oocyte mtDNA may be related to
another hypothesis - namely the reasoning behind inheritance of mtDNA
from the maternal gamete, and the reason why sperm swim and eggs remain
still.</div>
<br>
<div>It goes something like this......&nbsp; If both gametes were motile,
then both would require ATP presumably from mitochondria, and this would
carry with it an associated level of mtDNA damage.&nbsp; By keeping one
gamete stationary (the egg), and then sacrificing the mtDNA of the motile
one (the sperm), the integrity of mtDNA in the progeny is
maintained.&nbsp; Of course, this would all go to pot if the maternal
mtDNA were mutated to begin with, so maybe there is some kind of index of
mtDNA integrity (such as respiratory function/Ca handling) upon which
oocytes are selected?</div>
<br>
<div>Paul</div>
<br>
<br>

<font color="#000080">_________________________________________<br>
</font><font color="#FF0000"><b>Dr. Paul S.
Brookes.</b>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
(brookes at uab.edu)<br>
</font><font color="#000080">UAB Department of Pathology,&nbsp;&nbsp;
G004 Volker Hall<br>
1670 University Blvd., Birmingham AL 35294 USA<br>
Tel (001) 205 934 1915&nbsp;&nbsp;&nbsp;&nbsp; Fax (001) 205 934
1775<br>
<a href="http://peir.path.uab.edu/brookes" eudora="autourl">http://peir.path.uab.edu/brookes</a><br>
<br>
<b>The quality of e-mails can go down as well as up<br>
</font></b></html>

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