some questions from Aubrey's book

Aubrey de Grey ag24 at mole.bio.cam.ac.uk
Mon Jan 17 16:33:33 EST 2000


Michael Rae wrote:

> mitochondria in CR animals spent
> more time in clean-burning state 3 and less time in dirty state 4, and
> that this was triggered by the change in thyroid hormone balance and
> output.  Has this been disproved, or are you unaware of it, or ...?

I'm unaware of it.  I'm aware that serum thyroid hormone is lowered in CR
and that low thyroid hormone is associated with low proton-permeability
of the inner membrane, but I don't think those add up to a shift to state
3 in CR.  I'd be grateful for the references.

Aubrey de Grey





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