Caloric restriction slows brain aging
Paul S. Brookes.
brookes at uab.edu
Wed Jul 5 14:27:29 EST 2000
tateg at keydatatech.com wrote:-
" If nothing else consider menopause in women. After she has had her chance
to have children her body just kind of says to heck with it and starts it's
inevitable decline. It's nature's way of discarding what is no longer
useful after it has served it's purpose. "
Rather than menopause as a simple disposal mechanism, I would consider it
more of a safety mechanism - i.e. if you don't get rid of the ability to
bear children, then you just end up with a load of birth-defected
children. Recent advances in fertility treatment have demonstrated that
women are all too willing to have children into their 50's and over. Thus,
the menopause is a safety switch in order to prevent the consequences of
such late reproduction. After all, what's the point in passing on your
genes unless they're in good shape.
WRT the comments on CR and gene arrays, the whole idea that identifying
genes changed in CR and then changing them by a pharmaco / genetic CR
mimicry approach is more than a little shortsighted, since many of the
effects of CR at the cellular level (e.g. decreased mitochondrial ROS
production) can be attributed to phenomena that appear to have no genetic
Dr. Paul S. Brookes. (brookes at uab.edu)
UAB Department of Pathology, G004 Volker Hall
1670 University Blvd., Birmingham AL 35294 USA
Tel (001) 205 934 1915 Fax (001) 205 934 1775
The quality of e-mails can go down as well as up
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