Caloric restriction slows brain aging

Paul S. Brookes. brookes at
Wed Jul 5 14:27:29 EST 2000

  tateg at wrote:-

" If nothing else consider menopause in women. After she has had her chance 
to have children her body just kind of says to heck with it and starts it's 
inevitable decline. It's nature's way of discarding what is no longer 
useful after it has served it's purpose. "

Rather than menopause as a simple disposal mechanism, I would consider it 
more of a safety mechanism - i.e. if you don't get rid of the ability to 
bear children, then you just end up with a load of birth-defected 
children.  Recent advances in fertility treatment have demonstrated that 
women are all too willing to have children into their 50's and over.  Thus, 
the menopause is a safety switch in order to prevent the consequences of 
such late reproduction.  After all, what's the point in passing on your 
genes unless they're in good shape.

WRT the comments on CR and gene arrays, the whole idea that identifying 
genes changed in CR and then changing them by a pharmaco / genetic CR 
mimicry approach is more than a little shortsighted, since many of the 
effects of CR at the cellular level (e.g. decreased mitochondrial ROS 
production) can be attributed to phenomena that appear to have no genetic 

Dr. Paul S. Brookes.            (brookes at
UAB Department of Pathology,   G004 Volker Hall
1670 University Blvd., Birmingham AL 35294 USA
Tel (001) 205 934 1915     Fax (001) 205 934 1775

The quality of e-mails can go down as well as up
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