Caloric restriction slows brain aging

Aubrey de Grey ag24 at
Sat Jul 8 07:32:59 EST 2000

Paul Brookes wrote:

> WRT the comments on CR and gene arrays, the whole idea that identifying 
> genes changed in CR and then changing them by a pharmaco / genetic CR 
> mimicry approach is more than a little shortsighted, since many of the 
> effects of CR at the cellular level (e.g. decreased mitochondrial ROS 
> production) can be attributed to phenomena that appear to have no genetic 
> basis.

Hang on: What is your preferred interpretation of how CR decreases
mitochondrial ROS production?  All the proposals I know of ARE based
on gene-expression changes.

Aubrey de Grey

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