Accuracy of Microarrays

Aettius at Aettius at
Wed Jul 26 03:07:39 EST 2000

I would be very careful in putting too much faith in those microarray 
studies. The experimental variation of an RT reaction (a key step involved in 
all microarrays) on the "signal" of a specific gene is between 40 and 60% in 
the hands of a professional. Statistical analyses rarely take this into 
account and you have people publishing 2 fold increases as "statistically 
highly significant". As a rule of thumb I would dismiss anything that is not 
at least 3 fold increased as a fluke or as unproven. 


PS I see you are still very active on this board Aubrey.


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