pathogens may induce senescence in podospora anserina

Doug Skrecky oberon at vcn.bc.ca
Sun Mar 12 23:33:04 EST 2000


Citations: 1-3
<1>
Authors
  Jamet-Vierny C.  Rossignol M.  Haedens V.  Silar P.
Institution
  Institut de Genetique et Microbiologie, URA 2225, Universite de Paris Sud,
  Orsay cedex, 91405, France.
Title
  What triggers senescence in Podospora
  anserina?.
Source
  Fungal Genetics & Biology.  27(1):26-35, 1999 Jun.
Abstract
  Senescence of Podospora anserina is
  triggered by a cytoplasmic and infectious factor (the determinant of
  senescence) and is always correlated with mitochondrial DNA modifications,
  especially with the accumulation of small circular subgenomic DNA molecules,
  the senDNAs. Several observations have suggested that the senDNAs could be
  the cytoplasmic and infectious determinant. However, we show here (1) that
  senDNA molecules can be transferred to a young culture without the
  cotransmission of the determinant of senescence and (2) that the determinant
  of senescence does not segregate as a mitochondrial DNA mutation. Overall,
  our data strongly argue that amplification of senDNA molecules in the
  mitochondria is not an intrinsic property of these small DNA molecules. They
  question the nature of the actual determinant of senescence. Copyright 1999
  Academic Press.

<2>
Authors
  Esser K.  Tudzynski P.
Title
  Prevention of senescence in the ascomycete Podospora
  anserina by the antibiotic tiamulin.
Source
  Nature.  265(5593):454-6, 1977 Feb 3.

<3>
Authors
  Esser K.  Keller W.
Title
  Genes inhibiting senescence in the ascomycete Podospora
  anserina.
Source
  Molecular & General Genetics.  144(1):107-10, 1976 Feb 27.
Abstract
  Senescence occurs in all wild strains of Podospora
  anserina after continued growth. This syndrome can be
  inhibited by a synergistic interaction of two linked genes, incoloris and
  vivax. Whereas the wild strain starts to become senescent after 26 d and the
  mutants incoloris and vivax after 42 and 66 d respectively, the double mutant
  shows no signs of aging after culture for more than one year.






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