extension of life-span with superoxide/catalase mimetics

Paul S. Brookes. brookes at uab.edu
Tue Sep 5 08:46:09 EST 2000


If they're talking about MnTBAP and the other related porphyrins, it should 
be remembered that they don't only scavenge superoxide, but also 
peroxynitrite and to some extent nitric oxide and a whole host of other 
reactive species.  Whilst these compounds might work in worms, mammalian 
studies haven't been so successful - they are quite toxic in rats.

PSB

_________________________________________
Dr. Paul S. Brookes.            (brookes at uab.edu)
UAB Department of Pathology,   G004 Volker Hall
1670 University Blvd., Birmingham AL 35294 USA
Tel (001) 205 934 1915     Fax (001) 205 934 1775
http://peir.path.uab.edu/brookes

The quality of e-mails can go down as well as up
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