Aubrey's "survival of the slowest" hypothesis

Iuval clejan clejan at
Wed Apr 11 14:15:42 EST 2001

If better ATP producing mitos are degraded faster (because of more
membrane damage etc), and if the cell regulates mt replication primarily
based on ATP availability, then in order to keep up ATP production, the
number of mitochondria in non replicating cells (whose mitos suffer some
progressive unrepaired DNA damage which degrades their ATP production)
has to increase. Has this been observed experimentally?

If not, is one forced to postulate some other mechanism regulating
mitochondrial replication besides ATP availability?


More information about the Ageing mailing list